ryanodine

Ryanodine is a poisonous diterpenoid found in the South American plant Ryania speciosa (Salicaceae). It was originally used as an insecticide.

Research

13,864 papers

Ryanodine Receptors for Drugs and Insecticides: An Overview.Mini reviews in medicinal chemistry · 2019
Role of ryanodine receptors.Critical reviews in biochemistry and molecular biology · 1994
Cardiac ryanodine receptors: is a severe loss-of-function not so severe after all?Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2022
Ryanodine-sensitive Ca2+ release mechanism in non-excitable cells (Review).International journal of molecular medicine · 2001
Subcellular localization and transcriptional regulation of brain ryanodine receptors. Functional implications.Cell calcium · 2023

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Wikidata facts

Mass: 493.2311817

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isomeric SMILES: C[C@H]1CC[C@@]2([C@@]3(C[C@]4([C@@]5([C@]([C@H]([C@@]3([C@]5([C@]2([C@@H]1O)O4)O)O)OC(=O)c6ccc[nH]6)(C(C)C)O)C)O)C)O
chemical formula: C₂₅H₃₅NO₉
canonical SMILES: O=C(OC1C(O)(C(C)C)C2(C)C3(O)OC45C(O)C(C)CCC4(O)C(C)(C3)C1(O)C52O)C6=CC=CN6
Commons category: Ryanodine

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Ryanodine is a poisonous diterpenoid found in the South American plant Ryania speciosa (Salicaceae). It was originally used as an insecticide.

The compound has extremely high affinity to the open-form ryanodine receptor, a group of calcium channels found in skeletal muscle, smooth muscle, and heart muscle cells. It binds with such high affinity to the receptor that it was used as a label for the first purification of that class of ion channels and gave its name to it.