SA-4503
Sign in to saveAlso known as SA4503, SA 4503, cutamesine
Cutamesine (SA 4503) is a synthetic sigma receptor agonist which is selective for the σ1 receptor, a chaperone protein mainly found in the endoplasmic reticulum of cells in the central nervous system. These σ1 receptors play a key role in the modulation of Ca2+ release and apoptosis. Cutamesine's activation of the σ1 receptor is tied to a variety of physiological phenomena in the CNS, including activation of dopamine-releasing neurons and repression of the MAPK/ERK pathway.
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 368.246378264
Show 3 more facts
- chemical formula
- C₂₃H₃₂N₂O₂
- canonical SMILES
- COC1=C(C=C(C=C1)CCN2CCN(CC2)CCCC3=CC=CC=C3)OC
- Commons category
- Cutamesine
Sources (2)
via Wikidata · CC0
~5 min read
Encyclopedic overview
12 sectionsContents
- Structure
- Affinity
- Causes of Affinity
- Binding Trends
- Physiological Effects
- Memory and Amnesia
- Depression
- Heart
- Hearing
- See also
- References
- External links
Cutamesine (SA 4503) is a synthetic sigma receptor agonist which is selective for the σ1 receptor, a chaperone protein mainly found in the endoplasmic reticulum of cells in the central nervous system. These σ1 receptors play a key role in the modulation of Ca2+ release and apoptosis. Cutamesine's activation of the σ1 receptor is tied to a variety of physiological phenomena in the CNS, including activation of dopamine-releasing neurons and repression of the MAPK/ERK pathway.
== Structure == The molecular formula for cutamesine is C23H32N2O2. This particular agonist is a piperazine, meaning that its core functional group is a six-membered heterocycle with two oppositely-placed nitrogen atoms. Two phenalkyl groups act as substituents for the two nitrogen atoms. The phenethyl group has methoxy groups on the 3 and 4 locations of the aromatic ring, while the phenpropyl group has no additional functional groups attached.
Excerpted from Wikipedia’s “SA-4503” article, available under the CC BY-SA 4.0 licence.