Structure via PubChem · Public domain (PubChem)
selfotel
Sign in to saveAlso known as SET755, CGS-19755, CGS19755
Selfotel (CGS-19755) is a drug which acts as a competitive NMDA antagonist, directly competing with glutamate for binding to the receptor. Initial studies showed it to have anticonvulsant, anxiolytic, analgesic and neuroprotective effects, and it was originally researched for the treatment of stroke, but subsequent animal and human studies showed phencyclidine-like effects, as well as limited efficacy and evidence for possible neurotoxicity under some conditions, and so clinical development was ultimately discontinued.
Chemical data
- Formula
- C7H14NO5P
- Molecular weight
- 223.16 g/mol
- IUPAC name
- (2S,4R)-4-(phosphonomethyl)piperidine-2-carboxylic acid
- SMILES
- C1CN[C@@H](C[C@@H]1CP(=O)(O)O)C(=O)O
- InChIKey
- LPMRCCNDNGONCD-RITPCOANSA-N
- XLogP
- -3.9
- Polar surface area
- 107 Ų
- H-bond donors
- 4
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Wikidata facts
- Subclass of
- carboxylic acid
- Mass
- 223.060959
Show 5 more facts
- chemical formula
- C₇H₁₄NO₅P
- isomeric SMILES
- C1CN[C@@H](C[C@@H]1CP(=O)(O)O)C(=O)O
- canonical SMILES
- C1CNC(CC1CP(=O)(O)O)C(=O)O
- World Health Organisation international non-proprietary name
- selfotel
- Commons category
- Selfotel
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Selfotel (CGS-19755) is a drug which acts as a competitive NMDA antagonist, directly competing with glutamate for binding to the receptor. Initial studies showed it to have anticonvulsant, anxiolytic, analgesic and neuroprotective effects, and it was originally researched for the treatment of stroke, but subsequent animal and human studies showed phencyclidine-like effects, as well as limited efficacy and evidence for possible neurotoxicity under some conditions, and so clinical development was ultimately discontinued.
== References ==
Excerpted from Wikipedia’s “selfotel” article, available under the CC BY-SA 4.0 licence.