Structure via PubChem · Public domain (PubChem)
spermidine
Sign in to saveAlso known as 4-azaoctamethylenediamine, 1,5,10-triazadecane, 4-azaoctane-1,8-diamine, N-(3-aminopropyl)butane-1,4-diamine, N-(3-Aminopropyl)-1,4-diamino-butane, SPD, 1,8-Diamino-4-azaoctane, N-(gamma-Aminopropyl)tetramethylenediamine
Spermidine is a polyamine compound () originally isolated from semen and also found in ribosomes and living tissues and has various metabolic functions in organisms.
Chemical data
- Formula
- C7H19N3
- Molecular weight
- 145.25 g/mol
- IUPAC name
- N'-(3-aminopropyl)butane-1,4-diamine
- SMILES
- C(CCNCCCN)CN
- InChIKey
- ATHGHQPFGPMSJY-UHFFFAOYSA-N
- XLogP
- -1
- Polar surface area
- 64.1 Ų
- H-bond donors
- 3
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Research
15,583 papers- Spermidine - an old molecule with a new age-defying immune function.Trends in cell biology · 2024
- Spermidine improves gut barrier integrity and gut microbiota function in diet-induced obese mice.Gut microbes · 2020
- Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans?Autophagy · 2019
- Spermidine as a target for cancer therapy.Pharmacological research · 2020
- Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice.Aging · 2020
via PubMed
Wikidata facts
- Mass
- 145.158
Show 4 more facts
- chemical formula
- C₇H₁₉N₃
- canonical SMILES
- C(CCNCCCN)CN
- melting point
- 24
- Commons category
- Spermidine
via Wikidata · CC0
~5 min read
Article
7 sectionsContents
- Function
- Biosynthesis
- Biochemical actions
- Sources
- Uses
- References
- External links
Spermidine is a polyamine compound () originally isolated from semen and also found in ribosomes and living tissues and has various metabolic functions in organisms.
==Function== Spermidine synchronizes an array of biological processes, (such as Ca2+, Na+, K+ -ATPase) thus maintaining membrane potential and controlling intracellular pH and volume. Spermidine regulates biological processes, such as Ca2+ influx by glutamatergic N-methyl-D-aspartate receptor (NMDA receptor), which has been associated with nitric oxide synthase (NOS) and cGMP/PKG pathway activation and a decrease of Na+,K+-ATPase activity in cerebral cortex synaptosomes.