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Org 26576
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ORG-26576 is an ampakine originally developed by Cortex Pharmaceuticals and then licensed to Organon International for development. In animal studies it has been shown to effectively potentiate AMPA receptor function, leading to increased BDNF release and enhanced neuronal differentiation and survival, as well as producing nootropic effects in standardised assays. Development as an antidepressant has been halted due to a failed Phase II trial for major depressive disorder.
Wikidata facts
- Mass
- 204.09
Show 3 more facts
- chemical formula
- C₁₁H₁₂N₂O₂
- canonical SMILES
- C1CC2COC3=C(C=CC=N3)C(=O)N2C1
- isomeric SMILES
- C1C[C@H]2COC3=C(C=CC=N3)C(=O)N2C1
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ORG-26576 is an ampakine originally developed by Cortex Pharmaceuticals and then licensed to Organon International for development. In animal studies it has been shown to effectively potentiate AMPA receptor function, leading to increased BDNF release and enhanced neuronal differentiation and survival, as well as producing nootropic effects in standardised assays. Development as an antidepressant has been halted due to a failed Phase II trial for major depressive disorder.
== See also == AMPA receptor positive allosteric modulator