Structure via PubChem · Public domain (PubChem)
melarsoprol
Sign in to saveMelarsoprol is an arsenic-containing medication used for the treatment of sleeping sickness (African trypanosomiasis). It is specifically used for second-stage disease caused by Trypanosoma brucei rhodesiense when the central nervous system is involved. For Trypanosoma brucei gambiense, eflornithine or fexinidazole is usually preferred. It is effective in about 95% of people. It is given by injection and is known by patients as "fire in the veins".
Key facts
- Drug.tradename
- Arsobal
- Drug.Verifiedfields
- changed
- Drug.verifiedrevid
- 462248197
- Drug.IUPAC_name
- (2-{4-[(4,6-Diamino-1,3,5-triazin-2-yl)amino]phenyl}-1,3,2-dithiarsolan-4-yl)methanol
- Drug.image
- Melarsoprol2DCSD.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 250
- Drug.image2
- Melarsoprol-3D-spacefill.png
- Drug.image_class2
- bg-transparent
- Drug.synonyms
- Mel B, Melarsen Oxide-BAL
- Drug.routes_of_administration
- IV
- Drug.elimination_half life
- 35 hours
- Drug.excretion
- Kidney
- Drug.CAS_number
- 494-79-1
- Drug.ATC_prefix
- P01
- Drug.ATC_suffix
- CD01
- Drug.PubChem
- 10311
- Drug.ChemSpiderID
- 9889
via Wikipedia infobox
Chemical data
- Formula
- C12H15AsN6OS2
- Molecular weight
- 398.3 g/mol
- IUPAC name
- [2-[4-[(4,6-diamino-1,3,5-triazin-2-yl)amino]phenyl]-1,3,2-dithiarsolan-4-yl]methanol
- SMILES
- C1C(S[As](S1)C2=CC=C(C=C2)NC3=NC(=NC(=N3)N)N)CO
- InChIKey
- JCYZMTMYPZHVBF-UHFFFAOYSA-N
- Polar surface area
- 174 Ų
- H-bond donors
- 4
- H-bond acceptors
- 9
- Formal charge
- 0
via PubChem
Research
470 papers- Melarsoprol Resistance in African Trypanosomiasis.Trends in parasitology · 2018
- Melarsoprol-cyclodextrins inclusion complexes.International journal of pharmaceutics · 2005
- Slow-release melarsoprol microparticles.International journal of pharmaceutics · 2002
- [Melarsoprol].Medecine tropicale : revue du Corps de sante colonial · 1999
- Drug resistance in African trypanosomiasis: the melarsoprol and pentamidine story.Trends in parasitology · 2013
via PubMed
~10 min read
Encyclopedic overview
12 sectionsContents
- Medical uses
- Available forms
- Pregnancy and breastfeeding
- Cautions
- Side effects
- Resistance
- Pharmacology
- Mechanism of action
- Pharmacokinetics
- Society and culture
- References
- External links
{{Infobox drug | Verifiedfields = changed | verifiedrevid = 462248197 | IUPAC_name = (2-{4-[(4,6-Diamino-1,3,5-triazin-2-yl)amino]phenyl}-1,3,2-dithiarsolan-4-yl)methanol | image = Melarsoprol2DCSD.svg | image_class = skin-invert-image | width = 250 | image2 = Melarsoprol-3D-spacefill.png | image_class2 = bg-transparent
| tradename = Arsobal | synonyms = Mel B, Melarsen Oxide-BAL | Drugs.com = | pregnancy_category = | legal_status = | routes_of_administration = IV
Excerpted from Wikipedia’s “melarsoprol” article, available under the CC BY-SA 4.0 licence.