Structure via PubChem · Public domain (PubChem)
fexinidazole
Sign in to saveFexinidazole is a medication used to treat African trypanosomiasis (sleeping sickness) caused by Trypanosoma brucei gambiense. It is effective against both first and second stage disease. It is taken by mouth.
In the Vinony graph
Within Vinony's link graph, fexinidazole is referenced by 42 other articles, and connects out to paromomycin, Trypanosoma brucei and Drugs for Neglected Diseases Initiative.
It is catalogued under topics including 4-Methylthiophenyl compounds, Antiparasitic agents and ECHA InfoCard ID from Wikidata.
Its subject is documented across 14 Wikipedia language editions.
Key facts
- Drug.H
- 13
- Drug.N
- 3
- Drug.O
- 3
- Drug.S
- 1
- Drug.drug_name
- Fexinidazole
- Drug.image
- Fexinidazole.svg
- Drug.image_class
- skin-invert-image
- Drug.DailyMedID
- Fexinidazole
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- P01
- Drug.ATC_suffix
- CA03
- Drug.legal_US
- Rx-only
- Drug.CAS_number
- 59729-37-2
- Drug.PubChem
- 68792
- Drug.DrugBank
- DB12265
- Drug.ChemSpiderID
- 62032
- Drug.UNII
- 306ERL82IR
- Drug.KEGG
- D11252
via Wikipedia infobox
Chemical data
- Formula
- C12H13N3O3S
- Molecular weight
- 279.32 g/mol
- IUPAC name
- 1-methyl-2-[(4-methylsulfanylphenoxy)methyl]-5-nitroimidazole
- SMILES
- CN1C(=CN=C1COC2=CC=C(C=C2)SC)[N+](=O)[O-]
- InChIKey
- MIWWSGDADVMLTG-UHFFFAOYSA-N
- XLogP
- 2.5
- Polar surface area
- 98.2 Ų
- H-bond donors
- 0
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2021
- Admin. routes
- oral
- Indications
- trypanosomiasis, visceral Leishmaniasis, human african trypanosomiasis, infection
via ChEMBL · EBI
Research
141 papers- Fexinidazole: First Global Approval.Drugs · 2019
- Fexinidazole.2006
- Fexinidazole.2012
- Fexinidazole for Human African Trypanosomiasis, the Fruit of a Successful Public-Private Partnership.Diseases (Basel, Switzerland) · 2022
- Fexinidazole for the treatment of human African trypanosomiasis.Drugs of today (Barcelona, Spain : 1998) · 2019
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 279.068
Show 3 more facts
- chemical formula
- C₁₂H₁₃N₃O₃S
- canonical SMILES
- CN1C(=CN=C1COC2=CC=C(C=C2)SC)[N+](=O)[O-]
- Commons category
- Fexinidazole
Sources (2)
via Wikidata · CC0
~8 min read
Encyclopedic overview
10 sectionsContents
- Medical use
- Sleeping sickness
- Efficacy and safety
- Mechanism of action
- History
- Society and culture
- Veterinary use
- Synthesis
- References
- External links
{{Infobox drug | drug_name = Fexinidazole | INN = | type = | image = Fexinidazole.svg | image_class = skin-invert-image | width = | alt = | caption =
| pronounce = | tradename = | Drugs.com = | MedlinePlus = | licence_CA = | licence_EU = | DailyMedID = Fexinidazole | licence_US = | pregnancy_AU = | pregnancy_AU_comment = | pregnancy_category= | routes_of_administration = By mouth | class = | ATCvet = | ATC_prefix = P01 | ATC_suffix = CA03 | ATC_supplemental =
Excerpted from Wikipedia’s “fexinidazole” article, available under the CC BY-SA 4.0 licence.