Structure via PubChem · Public domain (PubChem)
fexinidazole
Sign in to saveFexinidazole is a medication used to treat African trypanosomiasis (sleeping sickness) caused by Trypanosoma brucei gambiense. It is effective against both first and second stage disease. It is taken by mouth.
Key facts
- Drug.H
- 13
- Drug.N
- 3
- Drug.O
- 3
- Drug.S
- 1
- Drug.drug_name
- Fexinidazole
- Drug.image
- Fexinidazole.svg
- Drug.image_class
- skin-invert-image
- Drug.DailyMedID
- Fexinidazole
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- P01
- Drug.ATC_suffix
- CA03
- Drug.legal_US
- Rx-only
- Drug.CAS_number
- 59729-37-2
- Drug.PubChem
- 68792
- Drug.DrugBank
- DB12265
- Drug.ChemSpiderID
- 62032
- Drug.UNII
- 306ERL82IR
- Drug.KEGG
- D11252
via Wikipedia infobox
Chemical data
- Formula
- C12H13N3O3S
- Molecular weight
- 279.32 g/mol
- IUPAC name
- 1-methyl-2-[(4-methylsulfanylphenoxy)methyl]-5-nitroimidazole
- SMILES
- CN1C(=CN=C1COC2=CC=C(C=C2)SC)[N+](=O)[O-]
- InChIKey
- MIWWSGDADVMLTG-UHFFFAOYSA-N
- XLogP
- 2.5
- Polar surface area
- 98.2 Ų
- H-bond donors
- 0
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2021
- Admin. routes
- oral
- Indications
- trypanosomiasis, visceral Leishmaniasis, human african trypanosomiasis, infection
via ChEMBL · EBI
Research
141 papers- Fexinidazole: First Global Approval.Drugs · 2019
- Fexinidazole.2006
- Fexinidazole.2012
- Fexinidazole for Human African Trypanosomiasis, the Fruit of a Successful Public-Private Partnership.Diseases (Basel, Switzerland) · 2022
- Fexinidazole for the treatment of human African trypanosomiasis.Drugs of today (Barcelona, Spain : 1998) · 2019
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 279.068
Show 3 more facts
- chemical formula
- C₁₂H₁₃N₃O₃S
- canonical SMILES
- CN1C(=CN=C1COC2=CC=C(C=C2)SC)[N+](=O)[O-]
- Commons category
- Fexinidazole
Sources (2)
via Wikidata · CC0
~8 min read
Encyclopedic overview
10 sectionsContents
- Medical use
- Sleeping sickness
- Efficacy and safety
- Mechanism of action
- History
- Society and culture
- Veterinary use
- Synthesis
- References
- External links
{{Infobox drug | drug_name = Fexinidazole | INN = | type = | image = Fexinidazole.svg | image_class = skin-invert-image | width = | alt = | caption =
| pronounce = | tradename = | Drugs.com = | MedlinePlus = | licence_CA = | licence_EU = | DailyMedID = Fexinidazole | licence_US = | pregnancy_AU = | pregnancy_AU_comment = | pregnancy_category= | routes_of_administration = By mouth | class = | ATCvet = | ATC_prefix = P01 | ATC_suffix = CA03 | ATC_supplemental =
Excerpted from Wikipedia’s “fexinidazole” article, available under the CC BY-SA 4.0 licence.