albendazol

Also known as SK&F 62979, SK&F-62979, O-methyl N-(5-(propylthio)-2-benzimidazolyl)carbamate, 5-(propylthio)-2-carbomethoxyaminobenzimidazole, [5-(propylthio)-1H-benzimidazol-2-yl]carbamic acid methyl ester, O-methyl N-[5-(propylthio)-2-benzimidazolyl]carbamate, albendazole

Albendazole is a broad-spectrum antihelmintic and antiprotozoal agent of the benzimidazole type. It is used for the treatment of a variety of intestinal parasite infections, including ascariasis, pinworm infection, hookworm infection, trichuriasis, strongyloidiasis, taeniasis, clonorchiasis, opisthorchiasis, cutaneous larva migrans, giardiasis, and gnathostomiasis, among other diseases.

OverviewAI-generated

Albendazol is a chemical compound with the formula C₁₂H₁₅N₃O₂S. Its IUPAC name is methyl N-(6-propylsulfanyl-1H-benzimidazol-2-yl)carbamate. The substance has a mass of 265.088498 and a weight of 265.33. It features a melting point of 209 and a defined daily dose of 0.4.

Physicochemical properties include an xlogp of 2.9 and a topological polar surface area of 92.3. The molecule contains two hydrogen bond donors and four hydrogen bond acceptors, with a charge of 0. The canonical SMILES notation for the compound is CCCSC1=CC2=C(C=C1)N=C(N2)NC(=O)OC.

Albendazol is associated with a PubMed query count of 8754. It is referenced by 212 other encyclopedia articles.

Synthesized by Vinony from 19 facts across 4 sources: Wikidata, PubMed, PubChem, Vinony graph. Generated from structured data (not the Wikipedia text) and checked against those facts — may still contain errors.

Key facts

Drug.Watchedfields: changed
Drug.verifiedrevid: 477316402
Drug.image: Albendazole.svg
Drug.image_class: skin-invert-image
Drug.image2: Albendazole-from-xtal-2007-3D-balls.png
Drug.image_class2: bg-transparent
Drug.width2: 250
Drug.tradename: Albenza, others
Drug.MedlinePlus: a610019
Drug.DailyMedID: Albendazole
Drug.pregnancy_AU: D
Drug.routes_of_administration: By mouth
Drug.ATC_prefix: P02
Drug.ATC_suffix: CA03
Drug.legal_AU: S4
Drug.legal_CA: Rx-only
Drug.legal_UK: POM
Drug.legal_US: Rx-only

via Wikipedia infobox

Chemical data

Formula: C12H15N3O2S
Molecular weight: 265.33 g/mol
IUPAC name: methyl N-(6-propylsulfanyl-1H-benzimidazol-2-yl)carbamate
SMILES: CCCSC1=CC2=C(C=C1)N=C(N2)NC(=O)OC
InChIKey: HXHWSAZORRCQMX-UHFFFAOYSA-N
XLogP: 2.9
Polar surface area: 92.3 Å²
H-bond donors: 2
H-bond acceptors: 4
Formal charge: 0

via PubChem

Research

8,754 papers

Albendazole.The Journal of antimicrobial chemotherapy · 1998
Albendazole-Induced Liver Injury.American journal of therapeutics · 2021
Albendazole.Indian pediatrics · 1993
Praziquantel vs. albendazol for cysticercosis.Neurosurgery · 1988
Therapy for neurocysticercosis.Expert review of neurotherapeutics · 2004

via PubMed

~27 min read

Encyclopedic overview

18 sections

Contents

Medical uses
Ivermectin/albendazole
Contraindications
Side effects
Pregnancy
Overdose
Interactions
Pharmacology
Mechanism of action
Pharmacokinetics
History
Society and culture
Economics
Brand names
Research
Veterinary use
Meat
References

Common side effects include nausea, abdominal pain, and headache. Rare but potentially serious side effects include bone marrow suppression which usually improves on discontinuing the medication. Liver inflammation has been reported and those with prior liver problems are at greater risk. It is pregnancy category D in Australia, meaning it may cause harm if taken by pregnant women.

Excerpted from Wikipedia’s “albendazol” article, available under the CC BY-SA 4.0 licence.