Structure via PubChem · Public domain (PubChem)
suramin
Sign in to saveAlso known as CI-1003, suramine, 8,8'-[CARBONYLBIS[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid, Naganol, Suramine, Belganyl, Naphuride
Suramin is a medication used to treat African sleeping sickness and river blindness. It is the treatment of choice for sleeping sickness without central nervous system involvement. It is given by injection into a vein.
Chemical data
- Formula
- C51H40N6O23S6
- Molecular weight
- 1297.3 g/mol
- IUPAC name
- 5-(hydroxy-oxo-oxoniumylidene-lambda6-sulfanyl)-4-[[3-[[3-[[3-[[5-[[8-(hydroxy-oxo-oxoniumylidene-lambda6-sulfanyl)-6-sulfo-4-sulfonatonaphthalen-1-yl]carbamoyl]-2-methylphenyl]carbamoyl]phenyl]carbamoylamino]benzoyl]amino]-4-methylbenzoyl]amino]-7-sulfonaphthalene-1-sulfonate
- SMILES
- CC1=C(C=C(C=C1)C(=O)NC2=C3C(=CC(=CC3=C(C=C2)S(=O)(=O)[O-])S(=[OH+])(=O)[O-])S(=[OH+])(=O)O)NC(=O)C4=CC(=CC=C4)NC(=O)NC5=CC=CC(=C5)C(=O)NC6=C(C=CC(=C6)C(=O)NC7=C8C(=CC(=CC8=C(C=C7)S(=O)(=O)[O-])S(=[OH+])(=O)[O-])S(=[OH+])(=O)O)C
- InChIKey
- FIAFUQMPZJWCLV-UHFFFAOYSA-N
- XLogP
- 1.9
- Polar surface area
- 481 Ų
- H-bond donors
- 12
- H-bond acceptors
- 19
- Formal charge
- 0
via PubChem
Research
4,808 papers- Suramin.Cancer treatment reviews · 1994
- 100 Years of Suramin.Antimicrobial agents and chemotherapy · 2020
- Suramin.Cancer practice · 1995
- Suramin: potential in acute liver failure.Expert opinion on investigational drugs · 2004
- Suramin awakes?Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 1992
via PubMed
Wikidata facts
- Mass
- 1296.047
- Image
- Original free sample of Bayer 205, suramin powder, Germany, Wellcome L0059013.jpg
Show 3 more facts
- chemical formula
- C₅₁H₄₀N₆O₂₃S₆
- canonical SMILES
- CC1=C(C=C(C=C1)C(=O)NC2=C3C(=CC(=CC3=C(C=C2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)NC(=O)C4=CC(=CC=C4)NC(=O)NC5=CC=CC(=C5)C(=O)NC6=C(C=CC(=C6)C(=O)NC7=C8C(=CC(=CC8=C(C=C7)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)C
- Commons category
- Suramin
via Wikidata · CC0
~9 min read
Article
12 sectionsContents
- Medical uses
- Pregnancy and breastfeeding
- Adverse reactions
- Pharmacology
- Pharmacokinetics
- Mechanism of action
- Chemistry
- History
- Research
- References
- Further reading
- External links
{{Drugbox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 411355479 | image = Suramin 2D skeletal.svg | image_class = skin-invert-image | width = 360 | alt = | image2 = Suramin ball-and-stick 2H9T.png | image_class2 = bg-transparent | alt2 =
| tradename = Antrypol, 309 Fourneau, Bayer 205, others | Drugs.com = | pregnancy_category = | routes_of_administration = by injection only | ATC_prefix = P01 | ATC_suffix = CX02 | ATC_supplemental =