antineoplastic
Sign in to saveAlso known as Antitumor Drugs, antineoplastic agent, anticancer drug, Antitumor Agents, Antineoplastics, Antineoplastic Drugs, antineoplastic drug, Chemotherapeutic Anticancer Agents
Antineoplastic agents, also known as anticancer drugs or antineoplastic drugs, are medications used to treat malignant tumors. These drugs work through various mechanisms to kill or inhibit cancer cells to achieve the goal of treating malignant tumors. Based on their pharmacological actions, antineoplastic drugs can be divided into cytotoxic drugs and non-cytotoxic drugs, with the former primarily consisting of DNA-toxic drugs and the latter mainly comprising molecularly targeted antineoplastic drugs. Commonly used antineoplastic drugs include cisplatin, doxorubicin, paclitaxel, and imatinib.
Key facts
- Drug class.ATC_prefix
- L01
- Drug class.MeshID
- E02.183.750.500
- Drug class.Name
- Antineoplastic agents
- Drug class.Use
- Treatment of malignant tumors
- Drug class.Image
- Chemotherapy bottles NCI.jpg
- Drug class.Caption
- Clockwise from center: Bleomycin, vincristine, dacarbazine, cyclophosphamide, doxorubicin, etoposide
- Drug class.Biological_target
- Killing or inhibiting cancer cells
- Drug class.Alt
- Six antineoplastic drug formulations
via Wikipedia infobox
Research
1,507,826 papers- Antineoplastic agents.Critical care nursing quarterly · 1996
- Antineoplastic Agents: Environmental Prevalence and Adverse Outcomes in Aquatic Organisms.Environmental toxicology and chemistry · 2020
- Classification of antineoplastic drug-induced tissue damage: a Consensus of the Spanish Oncology Pharmacy Group.Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria · 2021
- Pharmacology of antineoplastic agents in pregnancy.Critical reviews in oncology/hematology · 1994
- Recent Advances in Therapeutic Drug Monitoring of Antineoplastic and Antimicrobial Agents in Children.Clinics in laboratory medicine · 2025
via PubMed
Wikidata facts
Show 2 more facts
- NCI Thesaurus ID
- C274
- Commons category
- Antineoplastic agents
Sources (1)
via Wikidata · CC0
~51 min read
Article
25 sectionsContents
- Uses
- History
- Classification
- General classification
- Specific drug types
- Mechanism of action
- Cytotoxic drugs
- Non-cytotoxic drugs
- Toxicology
- Adverse reactions of cytotoxic drugs
- Common toxic reactions
- Specific toxic reactions
- Long-term toxic reactions
- Adverse reactions of non-cytotoxic drugs
- Monoclonal antibody drugs
- Small-molecule kinase inhibitors
- Drug resistance
- Pharmaceutics
- Preparation methods
- Future development
- Target-based drug development
- See also
- Notes
- References
- External links
Antineoplastic agents, also known as anticancer drugs or antineoplastic drugs, are medications used to treat malignant tumors. These drugs work through various mechanisms to kill or inhibit cancer cells to achieve the goal of treating malignant tumors. Based on their pharmacological actions, antineoplastic drugs can be divided into cytotoxic drugs and non-cytotoxic drugs, with the former primarily consisting of DNA-toxic drugs and the latter mainly comprising molecularly targeted antineoplastic drugs. Commonly used antineoplastic drugs include cisplatin, doxorubicin, paclitaxel, and imatinib.
Traditional cytotoxic drugs, due to their lack of sufficient selectivity for cancer cells, cause varying degrees of damage to normal tissue cells while targeting cancer cells. However, with advancements in tumor molecular biology and translational medicine, antineoplastic drugs have evolved from traditional cytotoxic drugs to non-cytotoxic drugs. Non-cytotoxic drugs are characterized by high selectivity and a high therapeutic index, offering significant clinical advantages.