nocodazole
Sign in to saveAlso known as (5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)-carbamic acid methyl ester, N-(5-(2-thenoyl)-2-benzimidazolyl)carbamic acid methyl ester, methyl (5-(2-thienylcarbonyl))-1H-benzimidazole-2-ylcarbamate, R17,934, R-17934, R 17934, methyl N-(5-thenoyl-2-benzimidazolyl)carbamate, N-(5-(2-thienoyl)-2-benzimidazolyl)carbamic acid methyl ester
Nocodazole is an antineoplastic agent which exerts its effect in cells by interfering with the polymerization of microtubules. Microtubules are one type of fibre which constitutes the cytoskeleton, and the dynamic microtubule network has several important roles in the cell, including vesicular transport, forming the mitotic spindle and in cytokinesis. Several drugs including vincristine and colcemid are similar to nocodazole in that they interfere with microtubule polymerization.
Research
4,840 papers- Optimizing Cell Synchronization Using Nocodazole or Double Thymidine Block.Methods in molecular biology (Clifton, N.J.) · 2021
- Nocodazole Induced Suicidal Death of Human Erythrocytes.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2016
- Nocodazole-Induced Expression and Phosphorylation of Anillin and Other Mitotic Proteins Are Decreased in DNA-Dependent Protein Kinase Catalytic Subunit-Deficient Cells and Rescued by Inhibition of the Anaphase-Promoting Complex/Cyclosome with proTAME but Not Apcin.Molecular and cellular biology · 2020
- High LET radiation enhances nocodazole Induced cell death in HeLa cells through mitotic catastrophe and apoptosis.Journal of radiation research · 2011
- Nocodazole and cytochalasin D induce tetraploidy in mammalian cells.The American journal of physiology · 1984
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Has part
- carbon
- Mass
- 301.052
- Has use
- medication
Show 7 more facts
- chemical formula
- C₁₄H₁₁N₃O₃S
- melting point
- 256
- Commons category
- Nocodazole
- found in taxon
- Homo sapiens
- canonical SMILES
- COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=CS3
- World Health Organisation international non-proprietary name
- nocodazole
- subject has role
- antineoplastic
via Wikidata · CC0
~3 min read
Encyclopedic overview
3 sectionsContents
- Use in cell biology research
- See also
- References
Nocodazole is an antineoplastic agent which exerts its effect in cells by interfering with the polymerization of microtubules. Microtubules are one type of fibre which constitutes the cytoskeleton, and the dynamic microtubule network has several important roles in the cell, including vesicular transport, forming the mitotic spindle and in cytokinesis. Several drugs including vincristine and colcemid are similar to nocodazole in that they interfere with microtubule polymerization.
Nocodazole has been shown to decrease the oncogenic potential of cancer cells via another microtubules-independent mechanisms. Nocodazole stimulates the expression of LATS2 which potently inhibits the Wnt signaling pathway by abrogating the interaction between the Wnt-dependent transcriptional co-factors beta-catenin and BCL9.
Excerpted from Wikipedia’s “nocodazole” article, available under the CC BY-SA 4.0 licence.