Structure via PubChem · Public domain (PubChem)
rimexolone
Sign in to saveAlso known as Vexol
Rimexolone is a glucocorticoid steroid used to treat inflammation in the eye. It is marketed as a 1% eye drop suspension under the trade name Vexol by Alcon Laboratories, but was discontinued in the US and other countries.
In the Vinony graph
Within Vinony's link graph, rimexolone is referenced by 414 other articles, and connects out to biological half-life, mometasone furoate and fludrocortisone.
Vinony files it under Alcohols, CYP3A4 inducers and Diketones.
Its subject is documented across 12 Wikipedia language editions.
Chemical data
- Formula
- C24H34O3
- Molecular weight
- 370.5 g/mol
- IUPAC name
- (8S,9S,10R,11S,13S,14S,16R,17S)-11-hydroxy-10,13,16,17-tetramethyl-17-propanoyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
- SMILES
- CCC(=O)[C@]1([C@@H](C[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)C=C[C@]34C)O)C)C)C
- InChIKey
- QTTRZHGPGKRAFB-OOKHYKNYSA-N
- XLogP
- 3.5
- Polar surface area
- 54.4 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1994
- Admin. routes
- topical
- Indications
- eye inflammation, dry eye syndrome
via ChEMBL · EBI
Research
54 papers- Rimexolone.2006
- Rimexolone-induced intraocular pressure elevation.Eye (London, England) · 2001
- PMID 18031088BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 1997
- Rimexolone inhibits proliferation, cytokine expression and signal transduction of human CD4+ T-cells.Immunology letters · 2010
- Intraocular pressure-raising potential of 1.0% rimexolone in patients responding to corticosteroids.Archives of ophthalmology (Chicago, Ill. : 1960) · 1996
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 370.250795
- Has use
- medication
Show 7 more facts
- chemical formula
- C₂₄H₃₄O₃
- medical condition treated
- inflammation
- canonical SMILES
- CCC(=O)C1(C(CC2C1(CC(C3C2CCC4=CC(=O)C=CC34C)O)C)C)C
- isomeric SMILES
- CCC(=O)[C@]1([C@@H](C[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)C=C[C@]34C)O)C)C)C
- defined daily dose
- 20
- NCI Thesaurus ID
- C47705
- subject has role
- glucocorticoid
Sources (3)
via Wikidata · CC0
~2 min read
Encyclopedic overview
7 sectionsContents
- Medical uses
- Contraindications
- Side effects
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- References
Rimexolone is a glucocorticoid steroid used to treat inflammation in the eye. It is marketed as a 1% eye drop suspension under the trade name Vexol by Alcon Laboratories, but was discontinued in the US and other countries.
==Medical uses== Rimexolone is used to treat inflammation after eye surgery, to treat anterior uveitis, conjunctivitis and keratitis.
Excerpted from Wikipedia’s “rimexolone” article, available under the CC BY-SA 4.0 licence.