senecionine
Sign in to saveAlso known as aureine, Senecionin
Senecionine is a toxic pyrrolizidine alkaloid isolated from various botanical sources. It takes its name from the Senecio genus and is produced by many different plants in that genus, including Jacobaea vulgaris (Senecio jacobaea). It has also been isolated from several other plants, including Brachyglottis repanda, Emilia, Erechtites hieraciifolius, Petasites, Syneilesis, Crotalaria, Caltha leptosepala, and Castilleja.
Research
255 papersvia PubMed
Wikidata facts
- Mass
- 335.173273
Show 6 more facts
- chemical formula
- C₁₈H₂₅NO₅
- Commons category
- Senecionine
- canonical SMILES
- CC=C1CC(C(C(=O)OCC2=CCN3C2C(CC3)OC1=O)(C)O)C
- isomeric SMILES
- C/C=C\1/C[C@H]([C@@](C(=O)OCC2=CCN3[C@H]2[C@@H](CC3)OC1=O)(C)O)C
- median lethal dose (LD50)
- 61
- minimal lethal dose
- 33
Sources (2)
via Wikidata · CC0
~8 min read
Article
11 sectionsContents
- Toxicity
- Liver toxicity
- DNA damage
- Diagnosis
- Other bioactivity
- Treatment
- Biosynthesis and chemistry
- Metabolism and mechanism of action
- Biology and society
- See also
- References
Senecionine is a toxic pyrrolizidine alkaloid isolated from various botanical sources. It takes its name from the Senecio genus and is produced by many different plants in that genus, including Jacobaea vulgaris (Senecio jacobaea). It has also been isolated from several other plants, including Brachyglottis repanda, Emilia, Erechtites hieraciifolius, Petasites, Syneilesis, Crotalaria, Caltha leptosepala, and Castilleja.
The compound is toxic and consumption can lead to liver damage, cancer, and pyrrolizidine alkaloidosis. Because of this, consumption of plants that produce it has resulted in poisonings, both in humans and in animals.