sequence alignment
Sign in to saveprocess in bioinformatics that aligns (identifies equivalent sites within) molecular sequences
Research
122,091 papers- The Sequence Alignment/Map format and SAMtools.Bioinformatics (Oxford, England) · 2009
- MAFFT multiple sequence alignment software version 7: improvements in performance and usability.Molecular biology and evolution · 2013
- Sequence Alignment/Map format: a comprehensive review of approaches and applications.Briefings in bioinformatics · 2023
- Revisiting Evaluation of Multiple Sequence Alignment Methods.Methods in molecular biology (Clifton, N.J.) · 2021
- Developments in Algorithms for Sequence Alignment: A Review.Biomolecules · 2022
via PubMed
Wikidata facts
- Image
- Histone Alignment.png
Show 3 more facts
- Commons category
- Sequence alignment
- exact match
- edamontology.org/operation_0292
- equivalent class
- edamontology.org/data_0863
via Wikidata · CC0
~36 min read
Article
In bioinformatics, a sequence alignment is a way of arranging the sequences of DNA, RNA, or protein to identify regions of similarity that may be a consequence of functional, structural, or evolutionary relationships between the sequences. Aligned sequences of nucleotide or amino acid residues are typically represented as rows within a matrix. Gaps are inserted between the residues so that identical or similar characters are aligned in successive columns. Sequence alignments are also used for non-biological sequences such as calculating the distance cost between strings in a natural language, or to display financial data.
A sequence alignment, produced by ClustalO, of mammalian histone proteins. Sequences are the amino acids for residues 120-180 of the proteins. Residues that are conserved across all sequences are highlighted in grey. Below the protein sequences is a key denoting conserved sequence (*), conservative mutations (:), semi-conservative mutations (.), and non-conservative mutations ( ).