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Also known as Xerxes, Serse, HWV 40, HWV 40, Xerxes, HWV 40, Handel's Serse, Handel's Xerxes

thumb|upright=1.2|Title page of the libretto, London 1738 Serse (; English title: Xerxes; HWV 40) is an opera seria in three acts by George Frideric Handel. It was first performed in London on 15 April 1738. The Italian libretto was adapted by an unknown hand from that by Silvio Stampiglia (1664–1725) for an earlier opera of the same name by Giovanni Bononcini in 1694. Stampiglia's libretto was itself based on one by Nicolò Minato (ca.1627–1698) that was set by Francesco Cavalli in 1654. The opera is set in Persia (modern-day Iran) about 470 BC and is very loosely based upon Xerxes I of Persia