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SH2 may stand for: SH2 (classification), a Paralympic shooting classification SH2 domain (Src Homology 2), a protein domain within the Src oncoprotein SH-2 Seasprite, an American-built ship-based helicopter SH-2, an iteration of the SuperH CPU core developed by Hitachi Sh2, the second edition of the Sharpless catalog Shavrov Sh-2 (Ш-2), a Soviet flying boat State Highway 2, see List of highways numbered 2