Gene data
SIRT6- Name
- sirtuin 6
- Type
- protein-coding
- Position
- 4,174,104–4,182,604 (−)
- Aliases
- SIR2L6, hSIRT6
- Ensembl
- ENSG00000077463
- RefSeq RNA
- NM_001193285.3, NM_001321058.2, NM_001321059.2, NM_001321060.2, NM_001321061.2
- RefSeq protein
- NP_001180214.1, NP_001307987.1, NP_001307988.1, NP_001307989.1, NP_001307990.1
This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016].
Gene Ontology
Biological process
negative regulation of transcription by RNA polymerase IInegative regulation of transcription by RNA polymerase IInegative regulation of transcription by RNA polymerase IInegative regulation of transcription by RNA polymerase IIregulation of gluconeogenesisbase-excision repairdouble-strand break repairchromatin remodeling
Molecular function
Pathways
Nicotinate and nicotinamide metabolism - Homo sapiens (human)Thermogenesis - Homo sapiens (human)Central carbon metabolism in cancer - Homo sapiens (human)Signaling by NOTCHSignal TransductionPre-NOTCH Transcription and TranslationPre-NOTCH Expression and ProcessingDNA Double-Strand Break RepairHomology Directed RepairHDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
via MyGene.info
Gene · Ensembl
sirtuin 6
- Symbol
- SIRT6
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:4,174,104-4,182,604
- Strand
- Reverse (−)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI