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SPX can refer to: S&P 500, a stock market index Sequenced Packet Exchange, a networking protocol IATA code of Sphinx International Airport, an airport in Giza, Egypt Small Press Expo, an alternative comics convention SpaceX (SpX), a rocket manufacturer Sports Performance eXtreme, a sports shoe and clothing brand SPX Corporation, a Fortune 500 electronics company St. Pius X, the 257th Pope of the Roman Catholic Church. St Pius X College, Sydney, Australia St. Pius X Seminary, Roxas City, Philippines Superphénix, a nuclear power plant Skulduggery Pleasant: Resurrection, the 10th book in the Skulduggery Pleasant series A file extension used for Speex-encoded audio files The National Rail code for St Pancras International railway station in Greater London The former IATA and FAA code for Houston Gulf Airport