Streptolydigin

Also known as Afragilimycin A, Portamycin

Streptolydigin (Stl) is an antibiotic that works by inhibiting nucleic acid chain elongation by binding to RNA polymerase, thus inhibiting RNA synthesis inside a cell. Streptolydigin inhibits bacterial RNA polymerase, but not eukaryotic RNA polymerase. It has antibacterial activity against a number of Gram positive bacteria.

Research

161 papers

Mycobacterium tuberculosis is resistant to streptolydigin.Tuberculosis (Edinburgh, Scotland) · 2013
Three pathway-specific regulators control streptolydigin biosynthesis in Streptomyces lydicus.Microbiology (Reading, England) · 2012
Antibiotic streptolydigin requires noncatalytic Mg2+ for binding to RNA polymerase.Antimicrobial agents and chemotherapy · 2014
Streptolydigin-resistant mutants in an evolutionarily conserved region of the beta' subunit of Escherichia coli RNA polymerase.The Journal of biological chemistry · 1995
Insights into the roles of exogenous glutamate and proline in improving streptolydigin production of Streptomyces lydicus with metabolomic analysis.Journal of industrial microbiology & biotechnology · 2013

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Wikidata facts

Mass: 600.3046809879999

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chemical formula: C₃₂H₄₄N₂O₉
canonical SMILES: CC1C2C=CC3(CO3)C(O2)(OC1C(C)C=C(C)C=CC(=C4C(=O)C(N(C4=O)C5CCC(C(O5)C)O)C(C)C(=O)NC)O)C
isomeric SMILES: C[C@H]1[C@H]2C=C[C@@]3(CO3)[C@](O2)(O[C@@H]1[C@H](C)/C=C(\C)/C=C/C(=C\4/C(=O)[C@@H](N(C4=O)[C@@H]5CC[C@@H]([C@@H](O5)C)O)[C@H](C)C(=O)NC)/O)C

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