Structure via PubChem · Public domain (PubChem)
succinyl-CoA
Sign in to saveAlso known as Succinyl-Coenzyme A, Coenzyme A, S-(hydrogen butanedioate), S-(Hydrogen succinyl)coenzyme A, S-(3-carboxy-propionyl)-CoA, S-(hydrogen succinyl)-CoA, S-(3-carboxypropionyl)-coenzyme-A, SUCC-CoA, Succinyl coenzyme A
Succinyl-coenzyme A, abbreviated as succinyl-CoA () or SucCoA, is a thioester of succinic acid and coenzyme A.
Chemical data
- Formula
- C25H40N7O19P3S
- Molecular weight
- 867.6 g/mol
- IUPAC name
- 4-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethylsulfanyl]-4-oxobutanoic acid
- SMILES
- CC(C)(COP(=O)(O)OP(=O)(O)OC[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)O)[C@H](C(=O)NCCC(=O)NCCSC(=O)CCC(=O)O)O
- InChIKey
- VNOYUJKHFWYWIR-ITIYDSSPSA-N
- XLogP
- -6.2
- Polar surface area
- 426 Ų
- H-bond donors
- 10
- H-bond acceptors
- 24
- Formal charge
- 0
via PubChem
~2 min read
Encyclopedic overview
5 sectionsContents
- Sources
- Fate
- Formation
- Interactive pathway map
- References
{{chembox | Verifiedfields = changed | verifiedrevid = 470472193 | ImageFile = Succinyl-CoA.svg | ImageClass = skin-invert | ImageSize = 150px | IUPACName = 4-[(2-{3-[(2R)-4-{[1,3-Dihydroxy-1,3-dioxo-3-(3′-O-phosphonoadenosin-5′-O-yl)-1λ5,3λ5-diphosphoxan-1-yl]oxy}-3,3-dimethylbutanamido]propanamido}ethyl)sulfanyl]-4-oxobutanoic acid | SystematicName = (9R)-1-[(2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5,10,14,19-pentaoxo-2,4,6-trioxa-18-thia-11,15-diaza-3λ5,5λ5-diphosphadocosan-22-oic acid | OtherNames = |Section1= |Section2= |Section3= }} Succinyl-coenzyme A, abbreviated as succinyl-CoA () or SucCoA, is a thioester of succinic acid and coenzyme A.
==Sources== It is an important intermediate in the citric acid cycle, where it is synthesized from α-ketoglutarate by α-ketoglutarate dehydrogenase through decarboxylation. During the process, coenzyme A is added.
Excerpted from Wikipedia’s “succinyl-CoA” article, available under the CC BY-SA 4.0 licence.