SV40
Sign in to saveAlso known as Simian virus 40, Simian vacuolating virus 40, SV-40
SV40 is an abbreviation for simian vacuolating virus 40 or simian virus 40, a polyomavirus that is found in both monkeys and humans. Like other polyomaviruses, SV40 is a DNA virus that is found to cause tumors in humans and animals, but most often persists as a dormant infection. SV40 has been widely studied as a model eukaryotic virus, leading to many early discoveries in eukaryotic DNA replication and transcription. ==Human disease== The hypothesis that SV40 might cause cancer in humans was a particularly controversial area of research, fuelled by the historical contamination of some batches
Research
14,161 papers- SV40 and human mesothelioma.Translational lung cancer research · 2020
- SV40: A human pathogen?Disease markers · 2001
- SV40 and human cancer: a review of recent data.International journal of cancer · 2007
- Association between SV40 and non-Hodgkin's lymphoma.Leukemia & lymphoma · 2003
- SV40 large T antigen targets multiple cellular pathways to elicit cellular transformation.Oncogene · 2005
via PubMed
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Article
15 sectionsContents
- Human disease
- p53 damage and carcinogenicity
- Polio vaccine contamination
- Gene therapy
- Virology
- Multiplicity reactivation
- Transcription
- Other animals
- History
- Culture and society
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SV40 is an abbreviation for simian vacuolating virus 40 or simian virus 40, a polyomavirus that is found in both monkeys and humans. Like other polyomaviruses, SV40 is a DNA virus that is found to cause tumors in humans and animals, but most often persists as a dormant infection. SV40 has been widely studied as a model eukaryotic virus, leading to many early discoveries in eukaryotic DNA replication and transcription. ==Human disease== The hypothesis that SV40 might cause cancer in humans was a particularly controversial area of research, fuelled by the historical contamination of some batches of polio vaccine with SV40 in the 1950s and 1960s. "Persuasive evidence now indicates that SV40 is causing infections in humans today and represents an emerging pathogen." However "It appears unlikely that SV40 infection alone is sufficient to cause human malignancy..."
===p53 damage and carcinogenicity=== It has been suggested that SV40 may act as a co-carcinogen with crocidolite asbestos to cause mesothelioma.