telcagepant

Also known as MK 0974, MK-0974, MK0974

Telcagepant (INN; development code MK-0974) is a calcitonin gene-related peptide receptor antagonist which was an investigational drug for the acute treatment and prevention of migraine, developed by Merck & Co.

Chemical data

Formula: C26H27F5N6O3
Molecular weight: 566.5 g/mol
IUPAC name: N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide
SMILES: C1C[C@H](C(=O)N(C[C@@H]1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
InChIKey: CGDZXLJGHVKVIE-DNVCBOLYSA-N
XLogP: 3
Polar surface area: 97.9 Å²
H-bond donors: 2
H-bond acceptors: 9
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Phase 3
Molecule type: Small molecule
Indications: migraine disorder

via ChEMBL · EBI

Wikidata facts

Subclass of: chemical compound
Mass: 566.206

Show 5 more facts

chemical formula: C₂₆H₂₇F₅N₆O₃
canonical SMILES: C1CC(C(=O)N(CC1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
isomeric SMILES: C1C[C@H](C(=O)N(C[C@@H]1C2=C(C(=CC=C2)F)F)CC(F)(F)F)NC(=O)N3CCC(CC3)N4C5=C(NC4=O)N=CC=C5
Commons category: Telcagepant
subject has role: calcitonin gene-related peptide receptor antagonist

Sources (2)

via Wikidata · CC0

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