Telomestatin
Sign in to saveTelomestatin is a macrocyclic chemical compound that acts by inhibiting the telomerase activity of in vitro cancer cells. It was first isolated from the bacteria Streptomyces anulatus. Telomestatin induces the formation of basket-type G-quadruplex (G4) structures from hybrid-type G-quadruplexes in the telomeric region. Upon formation of G4 structure there will be a decrease in the activity of the telomerase, which is involved in the replication of the telomeres and as a result the cell dies due to Hayflick type senescence.
Wikidata facts
- Subclass of
- alkaloid
- Mass
- 582.070615788
Show 4 more facts
- chemical formula
- C₂₆H₁₄N₈O₇S
- isomeric SMILES
- CC1=C(C2=NC(C3=NC(C4=NC(C5=NC(C6=NC(C7=NC(C8=N[C@@]9([H])CS8)=CO7)=CO6)=CO5)=CO4)=CO3)=C(C)O2)N=C9O1
- canonical SMILES
- N1=C2OC=C1C3=NC(=CO3)C4=NC(=CO4)C5=NC(C6=NC(C7=NC(C8=NC(=CO8)C9=NC2=CO9)=C(O7)C)=C(O6)C)CS5
- Commons category
- Telomestatin
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Encyclopedic overview
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- References
Telomestatin is a macrocyclic chemical compound that acts by inhibiting the telomerase activity of in vitro cancer cells. It was first isolated from the bacteria Streptomyces anulatus. Telomestatin induces the formation of basket-type G-quadruplex (G4) structures from hybrid-type G-quadruplexes in the telomeric region. Upon formation of G4 structure there will be a decrease in the activity of the telomerase, which is involved in the replication of the telomeres and as a result the cell dies due to Hayflick type senescence.
==References==
Excerpted from Wikipedia’s “Telomestatin” article, available under the CC BY-SA 4.0 licence.