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EntityQ426203· pop 5· linked from 3 articles

tezosentan

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Tezosentan is a non-selective ETA and ETB receptor antagonist. It acts as a vasodilator and was designed by Actelion as a therapy for patients with acute heart failure. However, studies showed that tezosentan did not improve dyspnea or reduce the risk of fatal or nonfatal cardiovascular events.

Research

199 papers

Repurposing of the Drug Tezosentan for Cancer Therapy.Current issues in molecular biology · 2023
Tezosentan in the treatment of acute heart failure.The Annals of pharmacotherapy · 2003
Tezosentan in the management of decompensated heart failure.Cardiology in review · 2005
Tezosentan. Actelion/Genentech.Current opinion in investigational drugs (London, England : 2000) · 2003
Tezosentan attenuates organ injury and mesenteric blood flow decrease in endotoxemia and cecal ligation and puncture.The Journal of surgical research · 2007

Wikidata facts

Mass: 605.181

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chemical formula: C₂₇H₂₇N₉O₆S
canonical SMILES: CC(C)C1=CN=C(C=C1)S(=O)(=O)NC2=C(C(=NC(=N2)C3=CC(=NC=C3)C4=NNN=N4)OCCO)OC5=CC=CC=C5OC
Commons category: Tezosentan

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References

Tezosentan is a non-selective ETA and ETB receptor antagonist. It acts as a vasodilator and was designed by Actelion as a therapy for patients with acute heart failure. However, studies showed that tezosentan did not improve dyspnea or reduce the risk of fatal or nonfatal cardiovascular events.

== References ==

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Categories

2-Methoxyphenyl compounds Alcohols Arylsulfonamides Chemical pages without DrugBank identifier Diaryl ethers Disubstituted pyridines Drugs not assigned an ATC code Drugs with no legal status Endothelin receptor antagonists Isopropyl compounds Pyrimidines Tetrazoles Vasodilators