transdifferentiation
Sign in to saveAlso known as GO:0060290, cell transdifferentiation
Transdifferentiation, also known as lineage reprogramming, is the process in which one mature somatic cell is transformed into another mature somatic cell without undergoing an intermediate pluripotent or progenitor cell stage. It is a type of metaplasia, which includes all cell fate switches, including the interconversion of stem cells. Current uses of transdifferentiation include disease modeling and drug discovery and in the future may include gene therapy and regenerative medicine. The term 'transdifferentiation' was originally coined by Selman and Kafatos in 1974 to describe a change in c
Research
10,543 papers- Chemical Transdifferentiation of Somatic Cells: Unleashing the Power of Small Molecules.Biomedicines · 2023
- Cellular communication network factor 2 regulates smooth muscle cell transdifferentiation and lipid accumulation in atherosclerosis.Cardiovascular research · 2024
- Transcriptomic and epigenetic mechanisms controlling cholangiocyte transdifferentiation into hepatocytes.Journal of hepatology · 2026
- Targeting β-cell dedifferentiation and transdifferentiation: opportunities and challenges.Endocrine connections · 2021
- Transdifferentiation in developmental biology, disease, and in therapy.Developmental dynamics : an official publication of the American Association of Anatomists · 2007
via PubMed
~12 min read
Article
18 sectionsContents
- Discovery
- Natural examples
- Induced and therapeutic examples
- Methods
- Lineage-instructive approach
- Initial epigenetic activation phase approach
- Pharmacological agents
- Mechanism of action
- Mogrify algorithm
- Issues
- Evaluation
- Transition from mouse to human cells
- Order of transcription factor expression
- Immunogenicity
- Method of transfection
- Differences with pluripotent reprogramming
- See also
- References
Transdifferentiation, also known as lineage reprogramming, is the process in which one mature somatic cell is transformed into another mature somatic cell without undergoing an intermediate pluripotent or progenitor cell stage. It is a type of metaplasia, which includes all cell fate switches, including the interconversion of stem cells. Current uses of transdifferentiation include disease modeling and drug discovery and in the future may include gene therapy and regenerative medicine. The term 'transdifferentiation' was originally coined by Selman and Kafatos in 1974 to describe a change in cell properties as cuticle-producing cells became salt-secreting cells in silk moths undergoing metamorphosis.
==Discovery== Davis et al. 1987 reported the first instance of transdifferentiation where a cell changed from one adult cell type to another. Forcing mouse embryonic fibroblasts to express MyoD was found to be sufficient to turn those cells into myoblasts.