triapine
Sign in to saveTriapine (also known as 3-aminopyridine-2-carboxaldehyde thiosemicarbazone or 3-AP) is an investigational drug that is being evaluated for the treatment of cancer. It is a thiosemicarbazone derivative of 3-aminopyridine-2-carboxaldehyde. It presents an N-N-S array of donor sites that strongly bind iron, robbing iron-containing enzymes of their prosthetic group.
Wikidata facts
- Mass
- 195.058
Show 3 more facts
- canonical SMILES
- C1=CC(=C(N=C1)C=NNC(=S)N)N
- chemical formula
- C₇H₉N₅S
- isomeric SMILES
- C1=CC(=C(N=C1)/C=N/NC(=S)N)N
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Article
4 sectionsContents
- Pharmacology
- Development
- References
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Triapine (also known as 3-aminopyridine-2-carboxaldehyde thiosemicarbazone or 3-AP) is an investigational drug that is being evaluated for the treatment of cancer. It is a thiosemicarbazone derivative of 3-aminopyridine-2-carboxaldehyde. It presents an N-N-S array of donor sites that strongly bind iron, robbing iron-containing enzymes of their prosthetic group.
It belongs to the family of drugs called ribonucleotide reductase inhibitors.