Structure via PubChem · Public domain (PubChem)
Trolox
Sign in to saveAlso known as 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxylic acid
Trolox (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid) is a water-soluble analog of vitamin E sold by Hoffman-LaRoche. It is an antioxidant like vitamin E and it is used in biological or biochemical applications to reduce oxidative stress or damage.
Chemical data
- Formula
- C14H18O4
- Molecular weight
- 250.29 g/mol
- IUPAC name
- 6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromene-2-carboxylic acid
- SMILES
- CC1=C(C2=C(CCC(O2)(C)C(=O)O)C(=C1O)C)C
- InChIKey
- GLEVLJDDWXEYCO-UHFFFAOYSA-N
- XLogP
- 2.8
- Polar surface area
- 66.8 Ų
- H-bond donors
- 2
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
7,086 papers- Trolox Reduces Neuroblastoma-Induced Oxidative Stress and Inflammation.Turkish neurosurgery · 2024
- Phenylacetyl-/Trolox- Amides: Synthesis, Sigma-1, HDAC-6, and Antioxidant Activities.International journal of molecular sciences · 2023
- The effect of Trolox on the rabbit anal sphincterotomy repair.BMC gastroenterology · 2023
- Trolox aids coenzyme Q(10) in neuroprotection against NMDA induced damage via upregulation of VEGF in rat model of glutamate excitotoxicity.Experimental eye research · 2024
- Therapeutic Potential of Trolox and Its Synthetic Derivatives as Multifunctional Bioactive Molecules in Periodontal Disease Management.Drug development research · 2025
via PubMed
Wikidata facts
- Subclass of
- carboxylic acid
- Mass
- 250.121
Show 4 more facts
- found in taxon
- Schisandra chinensis
- canonical SMILES
- CC1=C(C(=C2CCC(OC2=C1C)(C)C(=O)O)C)O
- chemical formula
- C₁₄H₁₈O₄
- subject has role
- antioxidant
via Wikidata · CC0
~2 min read
Encyclopedic overview
1 sectionsContents
- References
Trolox (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid) is a water-soluble analog of vitamin E sold by Hoffman-LaRoche. It is an antioxidant like vitamin E and it is used in biological or biochemical applications to reduce oxidative stress or damage.
Trolox equivalent antioxidant capacity (TEAC) is a measurement of antioxidant strength based on Trolox, measured in units called Trolox Equivalents (TE), e.g. micromolTE/100 g. Due to the difficulties in measuring individual antioxidant components of a complex mixture (such as blueberries or tomatoes), Trolox equivalency is used as a benchmark for the antioxidant capacity of such a mixture. Trolox equivalency is most often measured using the ABTS decolorization assay. The TEAC assay is used to measure antioxidant capacity of foods, beverages and supplements. Ferric reducing ability of plasma (FRAP) is an antioxidant capacity assays which uses Trolox as a standard.
Excerpted from Wikipedia’s “Trolox” article, available under the CC BY-SA 4.0 licence.