turosteride
Sign in to saveTurosteride (FCE-26,073) is a selective inhibitor of the enzyme 5α-reductase which was under investigation by GlaxoSmithKline for the treatment of benign prostatic hyperplasia (BPH), but was never marketed. Similarly to finasteride, turosteride is selective for the type II isoform of 5α-redcutase, with about 15-fold selectivity for it over type I isoform of the enzyme. In animal studies it has been shown to inhibit prostate size and retard tumor growth. It may also be useful for the treatment of acne and hair loss.
Research
9 papersvia PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 459.346
Show 5 more facts
- chemical formula
- C₂₇H₄₅N₃O₃
- isomeric SMILES
- CC(C)NC(=O)N(C(C)C)C(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@@H]4[C@@]3(CCC(=O)N4C)C)C
- canonical SMILES
- CC(C)NC(=O)N(C(C)C)C(=O)C1CCC2C1(CCC3C2CCC4C3(CCC(=O)N4C)C)C
- subject has role
- 5-alpha-reductase inhibitors
- Commons category
- Turosteride
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Encyclopedic overview
2 sectionsContents
- See also
- References
Turosteride (FCE-26,073) is a selective inhibitor of the enzyme 5α-reductase which was under investigation by GlaxoSmithKline for the treatment of benign prostatic hyperplasia (BPH), but was never marketed. Similarly to finasteride, turosteride is selective for the type II isoform of 5α-redcutase, with about 15-fold selectivity for it over type I isoform of the enzyme. In animal studies it has been shown to inhibit prostate size and retard tumor growth. It may also be useful for the treatment of acne and hair loss.
== See also == 5α-Reductase inhibitor FCE 28,260
Excerpted from Wikipedia’s “turosteride” article, available under the CC BY-SA 4.0 licence.