VWA2

Also known as AMACO, CCSP-2, NET42, von Willebrand factor A domain containing 2, CCSP2

von Willebrand factor A domain-containing protein 2, also known as A domain-containing protein similar to matrilin and collagen (AMACO), is a protein that in humans is encoded by the VWA2 gene.

Gene data

VWA2

Name: von Willebrand factor A domain containing 2
Type: protein-coding
Position: 114,239,246–114,294,489 (+)
Aliases: AMACO, CCSP-2, CCSP2, NET42
Ensembl: ENSG00000165816
RefSeq RNA: NM_001272046.2, NM_001320804.1, NM_198496.1, XM_011539754.3, XM_017016177.2
RefSeq protein: NP_001258975.1, NP_001307733.1, XP_011538056.1, XP_016871666.1, XP_016871667.1

This gene encodes a member of the von Willebrand factor A-like domain protein superfamily. The encoded protein is localized to the extracellular matrix and may serve as a structural component in basement membranes or in anchoring structures on scaffolds of collagen VII or fibrillin. This gene has been linked to type 1A diabetes and is a candidate serological marker for colon cancer. [provided by RefSeq, Jan 2013].

Gene Ontology

Biological process

calcium-independent cell-matrix adhesion regulation of insulin receptor signaling pathway

Molecular function

calcium ion binding protein binding identical protein binding identical protein binding

Cellular component

extracellular region extracellular region basement membrane basement membrane extracellular exosome

via MyGene.info

Gene · Ensembl

von Willebrand factor A domain containing 2

Symbol: VWA2
Biotype: Protein coding
Organism: Homo sapiens
Location: 10:114,239,246-114,294,489
Strand: Forward (+)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

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Encyclopedic overview

3 sections

Contents

References
Further reading
External links

von Willebrand factor A domain-containing protein 2, also known as A domain-containing protein similar to matrilin and collagen (AMACO), is a protein that in humans is encoded by the VWA2 gene.

AMACO is a member of the von Willebrand factor A-like (VWA) domain containing protein superfamily and consists of three VWA-like domains, two EGF-like domains, a cysteine-rich domain and a unique C-terminal domain. AMACO is an extracellular matrix protein and mostly deposited adjacent to basement membranes.

Excerpted from Wikipedia’s “VWA2” article, available under the CC BY-SA 4.0 licence.

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