Structure via PubChem · Public domain (PubChem)
1,4-dihydropyridine
Sign in to save1,4-Dihydropyridine (DHP) is an organic compound with the formula CH2(CH=CH)2NH. The parent compound is uncommon, but derivatives of 1,4-dihydropyridine are important commercially and biologically. The pervasive cofactors NADH and NADPH are derivatives of 1,4-dihydropyridine. Dihydropyridine calcium channel blockers are a class of L-type calcium channel blockers used in the treatment of hypertension. 1,2-Dihydropyridines are also known.
In the Vinony graph
Within Vinony's link graph, 1,4-dihydropyridine is referenced by 567 other articles, and connects out to digital object identifier, chemical formula and organic compound.
Vinony files it under Chembox image size set and Dihydropyridines.
Its subject is documented across 17 Wikipedia language editions.
Chemical data
- Formula
- C5H7N
- Molecular weight
- 81.12 g/mol
- IUPAC name
- 1,4-dihydropyridine
- SMILES
- C1C=CNC=C1
- InChIKey
- YNGDWRXWKFWCJY-UHFFFAOYSA-N
- XLogP
- 1.2
- Polar surface area
- 12 Ų
- H-bond donors
- 1
- H-bond acceptors
- 1
- Formal charge
- 0
via PubChem
Research
2,536 papers- 1,4-Dihydropyridine: A Dependable Heterocyclic Ring with the Promising and the Most Anticipable Therapeutic Effects.Mini reviews in medicinal chemistry · 2019
- Current Status on 1,4-Dihydropyridine Derivatives against Human Pathogenic Parasites.Current medicinal chemistry · 2023
- Genotoxic and genoprotective effects of 1,4-dihydropyridine derivatives: a brief review.Arhiv za higijenu rada i toksikologiju · 2023
- 1,4-Dihydropyridine Derivatives: Dihydronicotinamide Analogues-Model Compounds Targeting Oxidative Stress.Oxidative medicine and cellular longevity · 2016
- Atypical 1,4-dihydropyridine derivatives, an approach to neuroprotection and memory enhancement.Pharmacological research · 2016
via PubMed
Wikidata facts
- Mass
- 81.058
Show 3 more facts
- chemical formula
- C₅H₇N
- canonical SMILES
- C1C=CNC=C1
- subject has role
- calcium channel blocker
via Wikidata · CC0
~1 min read
Encyclopedic overview
5 sectionsContents
- Properties and reactions
- Hantzsch ester
- See also
- References
- External links
1,4-Dihydropyridine (DHP) is an organic compound with the formula CH2(CH=CH)2NH. The parent compound is uncommon, but derivatives of 1,4-dihydropyridine are important commercially and biologically. The pervasive cofactors NADH and NADPH are derivatives of 1,4-dihydropyridine. Dihydropyridine calcium channel blockers are a class of L-type calcium channel blockers used in the treatment of hypertension. 1,2-Dihydropyridines are also known.
==Properties and reactions== A recurring feature of 1,4-dihydropyridines is the presence of substituents at the 2- and 6-positions. Dihydropyridines are enamines, which otherwise tend to tautomerize or hydrolyze.
Excerpted from Wikipedia’s “1,4-dihydropyridine” article, available under the CC BY-SA 4.0 licence.