A1CF

Also known as ACF, ACF64, ACF65, APOBEC1CF, ASP, APOBEC1 complementation factor

APOBEC1 complementation factor is a protein that in humans is encoded by the A1CF gene.

Gene data

A1CF

Name: APOBEC1 complementation factor
Type: protein-coding
Position: 50,799,409–50,885,716 (−)
Aliases: ACF, ACF64, ACF65, APOBEC1CF, ASP
Ensembl: ENSG00000148584
RefSeq RNA: NM_001198818.2, NM_001198819.2, NM_001198820.2, NM_001370130.1, NM_001370131.1
RefSeq protein: NP_001185747.1, NP_001185748.1, NP_001185749.1, NP_001357059.1, NP_001357060.1

Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010].