ACAD8
Sign in to saveAlso known as ACAD-8, ARC42, acyl-CoA dehydrogenase family member 8, IBDH
Isobutyryl-CoA dehydrogenase, mitochondrial is an enzyme that in humans is encoded by the ACAD8 gene on chromosome 11.
In the Vinony graph
Within Vinony's link graph, ACAD8 is referenced by 3 other articles, and connects out to PubMed, human chromosome 11 and Ensembl genome database project.
Vinony files it under Genes on human chromosome 11 and Human proteins.
Its subject is documented across 4 Wikipedia language editions.
Gene data
ACAD8- Name
- acyl-CoA dehydrogenase family member 8
- Type
- protein-coding
- Position
- 134,253,510–134,267,494 (+)
- Aliases
- ACAD-8, ARC42, IBDH
- Ensembl
- ENSG00000151498
- RefSeq RNA
- NM_001441136.1, NM_001441137.1, NM_001441138.1, NM_014384.3, XM_047426768.1
- RefSeq protein
- NP_001428065.1, NP_001428066.1, NP_001428067.1, NP_055199.1, XP_047282724.1
This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes that catalyze the dehydrogenation of acyl-CoA derivatives in the metabolism of fatty acids or branch chained amino acids. The encoded protein is a mitochondrial enzyme that functions in catabolism of the branched-chain amino acid valine. Defects in this gene are the cause of isobutyryl-CoA dehydrogenase deficiency.[provided by RefSeq, Nov 2009].
Gene Ontology
Biological process
Molecular function
Cellular component
Pathways
via MyGene.info
Gene · Ensembl
acyl-CoA dehydrogenase family member 8
- Symbol
- ACAD8
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:134,253,510-134,267,494
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein ACAD8 PDB 1rx0.png
Show 8 more facts
- HomoloGene ID
- 8662
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/27034
- genomic start
- 134253548
- chromosome
- human chromosome 11
- genomic end
- 134135749
- cytogenetic location
- 11q25
- Commons category
- Isobutyryl-CoA dehydrogenase
Sources (6)
via Wikidata · CC0
~1 min read
Encyclopedic overview
6 sectionsContents
- Structure
- Clinical significance
- Function
- References
- External links
- Further reading
Isobutyryl-CoA dehydrogenase, mitochondrial is an enzyme that in humans is encoded by the ACAD8 gene on chromosome 11.
The protein encoded by ACAD8 is a mitochondrial protein belongs to the acyl-CoA dehydrogenase family of enzymes, which function to catalyze the dehydrogenation of acyl-CoA derivatives in the metabolism of fatty acids or branched-chain amino acids. ACAD8 functions in catabolism of the branched-chain amino acid valine.
Excerpted from Wikipedia’s “ACAD8” article, available under the CC BY-SA 4.0 licence.