ACE2

Key facts

Pdb

Ortholog search: PDBe RCSB

via Wikipedia infobox

Name

angiotensin converting enzyme 2

Type

protein-coding

Chromosome

X

Position

15,494,566–15,607,236 (−)

Aliases

ACEH

Ensembl

ENSG00000130234

RefSeq RNA

NM_001371415.1, NM_001386259.1, NM_001386260.1, NM_001388452.1, NM_001389402.1

RefSeq protein

NP_001358344.1, NP_001373188.1, NP_001373189.1, NP_001375381.1, NP_001376331.1

The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. ACE2 is known to be expressed in various human organs, and its organ- and cell-specific expression suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2, the latter is the causative agent of coronavirus disease-2019 (COVID-19). Multiple splice variants have been found for this gene and the dACE2 (or MIRb-ACE2) splice variant has been found to be interferon inducible. [provided by RefSeq, Nov 2020].

via MyGene.info

Gene · Ensembl

angiotensin converting enzyme 2

Symbol

ACE2

Biotype

Protein coding

Organism

Homo sapiens

Location

Chr X:15,494,290-15,607,236

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Image

Protein ACE2 PDB 1r42.png

via Wikidata · CC0