adapalene
Also known as Differin®, 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid, Adaferin, Adapalenum, Adapaleno, Differine
thumb|Adapalene Gel, sold as trade name Differin in China
Key facts
- Drug.metabolism
- Known to accumulate in the liver and GI-tract. In human, mouse, rat, rabbit, and dog cultured hepatocytes, metabolism appears to affect the methoxybenzene moiety but remains incompletely characterized. The major products of metabolism are glucuronides. Approximately 25% of the drug is metabolized; the rest is excreted as parent drug
- Drug.metabolites
- Glucuronides
- Drug.elimination_half life
- between 7 and 51 hours
- Drug.excretion
- Bile duct
- Drug.IUPHAR_ligand
- 5429
- Drug.CAS_number
- 106685-40-9
- Drug.PubChem
- 60164
- Drug.DrugBank
- DB00210
- Drug.ChemSpiderID
- 54244
- Drug.UNII
- 1L4806J2QF
- Drug.KEGG
- D01112
~7 min read
Article
13 sectionsContents
- Medical uses
- Off-label uses
- Cosmetic uses
- Side effects
- Pregnancy & lactation
- Interactions
- Pharmacology
- Pharmacokinetics
- Pharmacodynamics
- Metabolism
- History
- Research
- References
thumb|Adapalene Gel, sold as trade name Differin in China
Adapalene, sold under the brand name Differin among others, is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne, and is also used off-label to treat keratosis pilaris as well as other skin conditions. Studies have found adapalene is as effective as other retinoids, while causing less irritation. It also has several advantages over other retinoids. The adapalene molecule is more stable compared to tretinoin and tazarotene, which leads to less concern for photodegradation. It is also chemically more stable compared to the other two retinoids, allowing it to be used in combination with benzoyl peroxide. Due to its effects on keratinocyte proliferation and differentiation, adapalene is superior to tretinoin for the treatment of comedonal acne and is often used as a first-line agent. The Swiss company Galderma developed adapalene.