ADH1B

Also known as ADH2, HEL-S-117, alcohol dehydrogenase 1B (class I), beta polypeptide

Alcohol dehydrogenase 1B is an enzyme that in humans is encoded by the ADH1B gene.

Gene data

ADH1B

Name: alcohol dehydrogenase 1B (class I), beta polypeptide
Type: protein-coding
Aliases: ADH2, HEL-S-117

The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013].

via MyGene.info

Gene · Ensembl

alcohol dehydrogenase 1B (class I), beta polypeptide

Symbol: ADH1B
Biotype: Protein coding
Organism: Homo sapiens
Location: 4:99,304,971-99,321,659
Strand: Reverse (−)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein ADH1B PDB 1deh.png

Show 6 more facts

HomoloGene ID: 133563
exact match: identifiers.org/ncbigene/125
genomic end: 99352760
genomic start: 99304971
cytogenetic location: 4q23
Commons category: Alcohol dehydrogenase 1B

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Contents

Variants
Role in pathology
See also
References
Further reading
External links

Alcohol dehydrogenase 1B is an enzyme that in humans is encoded by the ADH1B gene.

The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol (beverage alcohol), retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein, known as ADH1B or beta-ADH, can form homodimers and heterodimers with ADH1A and ADH1C subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism (oxidizing ethanol into acetaldehyde). The acetaldehyde is further metabolized to acetate by aldehyde dehydrogenase genes. Three genes encoding the closely related alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster.