aerobactin
Sign in to saveAlso known as (8S,16S)-3,12,21-trihydroxy-2,10,14,22-tetraoxo-3,9,15,21-tetraazatricosane-8,12,16-tricarboxylic acid, Ferric-aerobactin
Aerobactin is a bacterial iron chelating agent (siderophore) found in E. coli and other Enterobacteriaceae species. It is a virulence factor enabling E. coli to sequester iron in iron-poor environments such as the urinary tract.
Research
913 papers- Hypervirulent Klebsiella pneumoniae.Clinical microbiology reviews · 2019
- Antimicrobial Resistance of Hypervirulent Klebsiella pneumoniae: Epidemiology, Hypervirulence-Associated Determinants, and Resistance Mechanisms.Frontiers in cellular and infection microbiology · 2017
- Aerobactin production as a virulence factor: a reevaluation.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 1988
- Aerobactin Synthesis Proteins as Antivirulence Targets in Hypervirulent Klebsiella pneumoniae.ACS infectious diseases · 2019
- Highly conserved composite transposon harbouring aerobactin iuc3 in Klebsiella pneumoniae from pigs.Microbial genomics · 2023
via PubMed
~1 min read
Encyclopedic overview
2 sectionsContents
- Other homologs
- References
Aerobactin is a bacterial iron chelating agent (siderophore) found in E. coli and other Enterobacteriaceae species. It is a virulence factor enabling E. coli to sequester iron in iron-poor environments such as the urinary tract.
Aerobactin is biosynthesized by the oxidation of lysine, catalyzed by the enzyme aerobactin synthase, which is then coupled to citric acid. The gene for this enzyme is found in the aerobactin operon, which is roughly 8 kilobases long and contains 5 or more genes in total.
Excerpted from Wikipedia’s “aerobactin” article, available under the CC BY-SA 4.0 licence.