allostasis
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Allostasis (/ˌɑːloʊˈsteɪsɪs/) is a physiological mechanism of regulation in which an organism anticipates and adjusts its energy use according to environmental demands. First proposed by Peter Sterling and Joseph Eyer in 1988, the concept of allostasis shifts the focus away from the body maintaining a rigid internal set-point, as in homeostasis, to the brain's ability and role to interpret environmental stress and coordinate changes in the body using neurotransmitters, hormones, and other signaling mechanisms.
Research
1,865 papers- Allostasis: a model of predictive regulation.Physiology & behavior · 2012
- Stress- and allostasis-induced brain plasticity.Annual review of medicine · 2011
- Adverse childhood experiences, allostasis, allostatic load, and age-related disease.Physiology & behavior · 2012
- Allostasis in Neuroendocrine Systems Controlling Reproduction.Endocrinology · 2023
- Sleep Deprivation and Circadian Disruption: Stress, Allostasis, and Allostatic Load.Sleep medicine clinics · 2015
via PubMed
~20 min read
Article
16 sectionsContents
- History
- Sterling and Eyer's model
- Variance from homeostasis
- Mechanism of action
- Regulation of the immune system
- Application of concept
- Allostatic load
- Types
- Paradigm of allostatic orchestration
- Role in evolutionary development
- Nature of concept
- Clinical significance
- Related terms
- See also
- References
- Further reading
Allostasis (/ˌɑːloʊˈsteɪsɪs/) is a physiological mechanism of regulation in which an organism anticipates and adjusts its energy use according to environmental demands. First proposed by Peter Sterling and Joseph Eyer in 1988, the concept of allostasis shifts the focus away from the body maintaining a rigid internal set-point, as in homeostasis, to the brain's ability and role to interpret environmental stress and coordinate changes in the body using neurotransmitters, hormones, and other signaling mechanisms.
Allostasis is believed to be involved not only in the body's stress response and adaptation to chronic stress but also in the regulation of the immune system and the development of chronic diseases such as hypertension and diabetes.