OPRK1

Also known as K-OR-1, KOR, KOR-1, OPRK, opioid receptor kappa 1, KOR1, KOP

protein-coding gene in the species Homo sapiens

In the Vinony graph

Vinony's link graph records 1,409 inbound references to OPRK1, and connects out to G protein-coupled recepteishon, downregulation and upregulation and addiction.

Vinony files it under Genes on human chromosome 8, Kappa-opioid receptor agonists and Opioid receptors.

Vinony links it to 12 Wikipedia language editions.

Gene data

OPRK1

Name: opioid receptor kappa 1
Type: protein-coding
Position: 53,225,724–53,251,740 (−)
Aliases: K-OR-1, KOP, KOR, KOR-1, KOR1, OPRK
Ensembl: ENSG00000082556
RefSeq RNA: NM_000912.5, NM_001282904.2, NM_001318497.2
RefSeq protein: NP_000903.2, NP_001269833.1, NP_001305426.1

This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017].