naltriben
Sign in to saveAlso known as naltrindole benzofuran, NTB
Naltriben is a potent and selective antagonist for the delta opioid receptor, which is used in scientific research. It has similar effects to the more widely used δ antagonist naltrindole, but with different binding affinity for the δ1 and δ2 subtypes, which makes it useful for distinguishing the subtype selectivity of drugs acting at the δ receptors. It also acts as a κ-opioid agonist at high doses.
Research
214 papers- Discovery of the therapeutic potential of naltriben against glutamate-induced neurotoxicity.Neurochemistry international · 2025
- Naltriben promotes tumor growth by activating the TRPM7-mediated development of the anti-inflammatory M2 phenotype.NPJ precision oncology · 2025
- Activation of TRPM7 by naltriben enhances migration and invasion of glioblastoma cells.Oncotarget · 2017
- Structural mechanisms of TRPM7 activation and inhibition.Nature communications · 2023
- Selective in vivo binding of [3H]naltriben to delta-opioid receptors in mouse brain.European journal of pharmacology · 1998
via PubMed
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Encyclopedic overview
2 sectionsContents
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- References
Naltriben is a potent and selective antagonist for the delta opioid receptor, which is used in scientific research. It has similar effects to the more widely used δ antagonist naltrindole, but with different binding affinity for the δ1 and δ2 subtypes, which makes it useful for distinguishing the subtype selectivity of drugs acting at the δ receptors. It also acts as a κ-opioid agonist at high doses.
== See also == Nalfurafine Nalmefene Naltrindole
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