Structure via PubChem · Public domain (PubChem)
naltriben
Sign in to saveAlso known as naltrindole benzofuran, NTB
Naltriben is a potent and selective antagonist for the delta opioid receptor, which is used in scientific research. It has similar effects to the more widely used δ antagonist naltrindole, but with different binding affinity for the δ1 and δ2 subtypes, which makes it useful for distinguishing the subtype selectivity of drugs acting at the δ receptors. It also acts as a κ-opioid agonist at high doses.
Chemical data
- Formula
- C26H25NO4
- Molecular weight
- 415.5 g/mol
- IUPAC name
- (1S,2S,13R,21R)-22-(cyclopropylmethyl)-11,14-dioxa-22-azaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5,7,9,15,17,19(25)-heptaene-2,16-diol
- SMILES
- C1CC1CN2CC[C@]34[C@@H]5C6=C(C[C@]3([C@H]2CC7=C4C(=C(C=C7)O)O5)O)C8=CC=CC=C8O6
- InChIKey
- ZHVWWEYETMPAMX-IFKAHUTRSA-N
- XLogP
- 3.6
- Polar surface area
- 66.1 Ų
- H-bond donors
- 2
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
214 papers- Discovery of the therapeutic potential of naltriben against glutamate-induced neurotoxicity.Neurochemistry international · 2025
- Naltriben promotes tumor growth by activating the TRPM7-mediated development of the anti-inflammatory M2 phenotype.NPJ precision oncology · 2025
- Activation of TRPM7 by naltriben enhances migration and invasion of glioblastoma cells.Oncotarget · 2017
- Structural mechanisms of TRPM7 activation and inhibition.Nature communications · 2023
- Selective in vivo binding of [3H]naltriben to delta-opioid receptors in mouse brain.European journal of pharmacology · 1998
via PubMed
Wikidata facts
- Mass
- 415.178358
Show 5 more facts
- chemical formula
- C₂₆H₂₅NO₄
- isomeric SMILES
- C1CC1CN2CC[C@]34[C@@H]5C6=C(C[C@]3([C@H]2CC7=C4C(=C(C=C7)O)O5)O)C8=CC=CC=C8O6
- canonical SMILES
- C1CC1CN2CCC34C5C6=C(CC3(C2CC7=C4C(=C(C=C7)O)O5)O)C8=CC=CC=C8O6
- subject has role
- opioid antagonist
- Commons category
- Naltriben
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Naltriben is a potent and selective antagonist for the delta opioid receptor, which is used in scientific research. It has similar effects to the more widely used δ antagonist naltrindole, but with different binding affinity for the δ1 and δ2 subtypes, which makes it useful for distinguishing the subtype selectivity of drugs acting at the δ receptors. It also acts as a κ-opioid agonist at high doses.
== See also == Nalfurafine Nalmefene Naltrindole
Excerpted from Wikipedia’s “naltriben” article, available under the CC BY-SA 4.0 licence.