nociceptin
Sign in to saveAlso known as N/OFQ, Orphanin FQ, PheGlyGlyPheThrGlyAlaArgLysSerAlaArgLysLeuAlaAsnGln, Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln, FGGFTGARKSARKLANQ, L-Phe-Gly-Gly-L-Phe-L-Thr-Gly-L-Ala-L-Arg-L-Lys-L-Ser-L-Ala-L-Arg-L-Lys-L-Leu-L-Ala-L-Asn-L-Gln, Nociceptin (1-17)
Nociceptin/orphanin FQ (N/OFQ), a 17-amino acid neuropeptide, is the endogenous ligand for the nociceptin receptor (NOP, ORL-1). Nociceptin acts as a potent anti-analgesic, effectively counteracting the effect of pain-relievers; its activation is associated with brain functions such as pain sensation and fear learning.
Key facts
- Protein.Name
- prepronociceptin
- Protein.HGNCid
- 9163
- Protein.Symbol
- PNOC
- Protein.EntrezGene
- 5368
- Protein.OMIM
- 601459
- Protein.RefSeq
- NM_006228
- Protein.UniProt
- Q13519
- Protein.Chromosome
- 8
- Protein.Arm
- p
- Protein.Band
- 21
via Wikipedia infobox
Research
2,228 papers- Nociceptin/orphanin FQ receptor system blockade as an innovative strategy for increasing resilience to stress.Peptides · 2021
- Nociceptin/orphanin-FQ modulation of learning and memory.Vitamins and hormones · 2015
- Potential of Nociceptin/Orphanin FQ Peptide Analogs for Drug Development.Chemistry & biodiversity · 2021
- Nociceptin and the micturition reflex.Peptides · 2000
- Nociceptin system as a target in sepsis?Journal of anesthesia · 2014
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Has part
- carbon
- Mass
- 1807.980549
Show 6 more facts
- chemical formula
- C₇₉H₁₂₉N₂₇O₂₂
- found in taxon
- Homo sapiens
- canonical SMILES
- CC(C)CC(C(=O)NC(C)C(=O)NC(CC(=O)N)C(=O)NC(CCC(=O)N)C(=O)O)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(C)NC(=O)CNC(=O)C(C(C)O)NC(=O)C(CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)C(CC2=CC=CC=C2)N
- isomeric SMILES
- C[C@H]([C@@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)O)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)[C@H](CC2=CC=CC=C2)N)O
- subject has role
- vasodilator agent
- Commons category
- Nociceptin
Sources (1)
via Wikidata · CC0
~6 min read
Encyclopedic overview
12 sectionsContents
- Roles of nociceptin
- Pain
- Mood disorders
- Drug abuse medications
- Learning and memory
- Cardiovascular system
- Renal system
- Immune system
- Digestive system
- See also
- References
- External links
Nociceptin/orphanin FQ (N/OFQ), a 17-amino acid neuropeptide, is the endogenous ligand for the nociceptin receptor (NOP, ORL-1). Nociceptin acts as a potent anti-analgesic, effectively counteracting the effect of pain-relievers; its activation is associated with brain functions such as pain sensation and fear learning.
The gene coding for prepronociceptin is located on Ch8p21 in humans. Nociceptin is derived from the prepronociceptin protein, as are a further two peptides, nocistatin and NocII, both of which inhibit N/OFQ receptor function. Nociceptin is the first example of reverse pharmacology; the NOP receptor was discovered before the endogenous ligand which was discovered by two separate groups in 1995.
Excerpted from Wikipedia’s “nociceptin” article, available under the CC BY-SA 4.0 licence.