bradykinin
Bradykinin (BK) (from Greek brady- 'slow' + -kinin, kīn(eîn) 'to move') is a peptide that promotes inflammation. It causes arterioles to dilate (enlarge) via the release of prostacyclin, nitric oxide, and endothelium-derived hyperpolarizing factor, and makes veins constrict via prostaglandin F2, thereby leading to leakage into capillary beds due to the increased pressure in the capillaries. Bradykinin consists of nine amino acids, and is a physiologically and pharmacologically active peptide of the kinin group of proteins.
Key facts
- Protein.Band
- 21
- Protein.Name
- kininogen 1
- Protein.HGNCid
- 6383
- Protein.Symbol
- KNG1
- Protein.AltSymbols
- KNG, BDK
- Protein.EntrezGene
- 3827
- Protein.OMIM
- 612358
- Protein.RefSeq
- NM_001102416
- Protein.UniProt
- P01042
- Protein.Chromosome
- 3
- Protein.Arm
- q
- Protein.LocusSupplementaryData
- -qter
- Protein family.Symbol
- Bradykinin
~8 min read
Article
11 sectionsContents
- Structure
- Metabolism
- Function
- Effects
- Receptors
- Disorders
- Therapeutic implications
- History
- See also
- References
- Bibliography
{{chembox | Watchedfields = changed | verifiedrevid = 443425952 |ImageFile = Bradykinin structure.svg |ImageClass = skin-invert-image |ImageFile1 = Bradykinin updated.png |ImageClass1 = bg-transparent |ImageSize = 250px |ImageSize1 = 250px |IUPACName = Bradykinin |SystematicName=(2S)-2-{(12S,32S,9S,12S,142S,17S)-11-[(2S)-2-Amino-5-(carbamimidoylamino)pentanoyl]-9-benzyl-12-(hydroxymethyl)-2,4,7,10,13,15-hexaoxo-5,8,11,16-tetraaza-1(2),3,14(1,2)-tripyrrolidina-19-benzenanonadecaphane-17-carboxamido}-5-(carbamimidoylamino)pentanoic acid |OtherNames= |Section1= |Section2= }}
Bradykinin (BK) (from Greek brady- 'slow' + -kinin, kīn(eîn) 'to move') is a peptide that promotes inflammation. It causes arterioles to dilate (enlarge) via the release of prostacyclin, nitric oxide, and endothelium-derived hyperpolarizing factor, and makes veins constrict via prostaglandin F2, thereby leading to leakage into capillary beds due to the increased pressure in the capillaries. Bradykinin consists of nine amino acids, and is a physiologically and pharmacologically active peptide of the kinin group of proteins.