diglyceride
Sign in to saveAlso known as diacylglycerol, diacylglyceride
A diglyceride, or diacylglycerol (DAG), is a glyceride consisting of two fatty acid chains covalently bonded to a glycerol molecule through ester linkages. Two possible forms exist, 1,2-diacylglycerols and 1,3-diacylglycerols. Diglycerides are natural components of food fats, though minor in comparison to triglycerides. DAGs can act as surfactants and are commonly used as emulsifiers in processed foods. DAG-enriched oil (particularly 1,3-DAG) has been investigated extensively as a fat substitute due to its ability to suppress the accumulation of body fat; with total annual sales of approximate
Research
10,642 papers- Discovery of a potent allosteric activator of DGKQ that ameliorates obesity-induced insulin resistance via the sn-1,2-DAG-PKCε signaling axis.Cell metabolism · 2023
- Insulin second messengers.BioEssays : news and reviews in molecular, cellular and developmental biology · 1997
- Ceramide synthesis inhibitors prevent lipid-induced insulin resistance through the DAG-PKCε-insulin receptor(T1150) phosphorylation pathway.Cell reports · 2024
- Determinants of increased muscle insulin sensitivity of exercise-trained versus sedentary normal weight and overweight individuals.Science advances · 2025
- DIGLYCERIDE RELEASE FROM INSECT FAT BODY: A POSSIBLE MEANS OF LIPID TRANSPORT.Science (New York, N.Y.) · 1964
via PubMed
Wikidata facts
Show 3 more facts
- Commons category
- Diglycerides
- canonical SMILES
- [*]OCC(CO[*])O[*]
- CXSMILES
- [*]OCC(CO[*])O[*] |$R;;;;;;R;;R$|
via Wikidata · CC0
~5 min read
Article
10 sectionsContents
- Production
- Food additive
- Biological functions
- Protein kinase C activation
- Munc13/UNC-13 activation
- Other
- Metabolism
- Insulin resistance
- See also
- References
A diglyceride, or diacylglycerol (DAG), is a glyceride consisting of two fatty acid chains covalently bonded to a glycerol molecule through ester linkages. Two possible forms exist, 1,2-diacylglycerols and 1,3-diacylglycerols. Diglycerides are natural components of food fats, though minor in comparison to triglycerides. DAGs can act as surfactants and are commonly used as emulsifiers in processed foods. DAG-enriched oil (particularly 1,3-DAG) has been investigated extensively as a fat substitute due to its ability to suppress the accumulation of body fat; with total annual sales of approximately USD 200 million in Japan since its introduction in the late 1990s till 2009.
==Production== Diglycerides are a minor component of many seed oils and are normally present at ~1–6%; or in the case of cottonseed oil as much as 10%. Industrial production is primarily achieved by a glycerolysis reaction between triglycerides and glycerol. The raw materials for this may be either vegetable oils or animal fats.