HTR2A

Name

5-hydroxytryptamine receptor 2A

Type

protein-coding

Position

46,831,546–46,897,076 (−)

Aliases

5-HT2A, HTR2

Ensembl

ENSG00000102468

RefSeq RNA

NM_000621.5, NM_001165947.5, NM_001378924.1

RefSeq protein

NP_000612.1, NP_001159419.2, NP_001365853.1

This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].