cabergoline

Also known as Cabaser®, Caberlin®, (8R)-6-allyl-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)ergoline-8-carboxamide, 1-((6-allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea, 1-[(6-allylergoline-8beta-yl)carbonyl]-1-[3-(dimethylamino)propyl]-3-ethylurea, 1-ethyl-3-(3'-dimethylamionpropyl)-2-(6'-allylergoline-8'beta-carbonyl)urea, (8beta)-N-[3-(dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)-ergoline-8-carboxamide, (8R)-6-Allyl-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)ergoline-8-carboxamide

Cabergoline, sold under the brand name Dostinex among others, is a dopaminergic medication used in the treatment of high prolactin levels, prolactinomas, Parkinson's disease, and for other indications. It is taken by mouth.

Key facts

Drug.Verifiedfields: changed
Drug.Watchedfields: changed
Drug.verifiedrevid: 477165198
Drug.image: Cabergoline Skeletal.png
Drug.image_class: skin-invert-image
Drug.width: 268
Drug.image2: Cabergoline_3D_Xtal_ballandstick.png
Drug.image_class2: bg-transparent
Drug.width2: 260
Drug.tradename: Dostinex, others
Drug.DailyMedID: Cabergoline
Drug.routes_of_administration: Oral
Drug.ATC_prefix: G02
Drug.ATC_suffix: CB03
Drug.legal_AU: S4
Drug.legal_US: Rx-only
Drug.bioavailability: 50–80%
Drug.protein_bound: Moderately bound (40–42%); concentration-independent

via Wikipedia infobox

Chemical data

Formula: C26H37N5O2
Molecular weight: 451.6 g/mol
IUPAC name: (6aR,9R,10aR)-N-[3-(dimethylamino)propyl]-N-(ethylcarbamoyl)-7-prop-2-enyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide
SMILES: CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@H]2[C@@H](CC3=CNC4=CC=CC2=C34)N(C1)CC=C
InChIKey: KORNTPPJEAJQIU-KJXAQDMKSA-N
XLogP: 3.4
Polar surface area: 71.7 Å²
H-bond donors: 2
H-bond acceptors: 4
Formal charge: 0

via PubChem

Research

2,371 papers

Cabergoline in acromegaly.Pituitary · 2017
Cabergoline for Lactation Inhibition After Second-Trimester Abortion or Pregnancy Loss: A Randomized Controlled Trial.Obstetrics and gynecology · 2023
Cabergoline Use and Pregnancy Outcomes: A Systematic Review.Birth defects research · 2025
Cabergoline: a review of its use in the inhibition of lactation for women living with HIV.Journal of the International AIDS Society · 2019
Pituitary acting drugs: cabergoline and pasireotide.Pituitary · 2022

via PubMed

Wikidata facts

Mass: 451.294725

Show 6 more facts

chemical formula: C₂₆H₃₇N₅O₂
canonical SMILES: CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=CNC4=CC=CC2=C34)N(C1)CC=C
isomeric SMILES: CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@H]2[C@@H](CC3=CNC4=CC=CC2=C34)N(C1)CC=C
World Health Organisation international non-proprietary name: cabergoline
defined daily dose: 0.5
Commons category: Cabergoline

Sources (4)

via Wikidata · CC0

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