Structure via PubChem · Public domain (PubChem)
methixene
Sign in to saveAlso known as TRE232, metixene, SJ-1977, Trest®, Metisene, Metixeno, Metixenum
Metixene (brand names Methixart, CholinFall, Tremonil, Trest), also known as methixene, is an anticholinergic used as an antiparkinsonian agent. It has also been reported to induce incomplete autophagy and cell death in metastatic cancer and brain metastases.
Chemical data
- Formula
- C20H23NS
- Molecular weight
- 309.5 g/mol
- IUPAC name
- 1-methyl-3-(9H-thioxanthen-9-ylmethyl)piperidine
- SMILES
- CN1CCCC(C1)CC2C3=CC=CC=C3SC4=CC=CC=C24
- InChIKey
- MJFJKKXQDNNUJF-UHFFFAOYSA-N
- XLogP
- 4.9
- Polar surface area
- 28.5 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1982
- Admin. routes
- oral
- Indications
- Parkinson disease
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 309.155121
- Has use
- medication
Show 5 more facts
- chemical formula
- C₂₀H₂₃NS
- canonical SMILES
- CN1CCCC(C1)CC2C3=CC=CC=C3SC4=CC=CC=C24
- World Health Organisation international non-proprietary name
- metixene
- defined daily dose
- 40.0
- medical condition treated
- Parkinson's disease
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Metixene (brand names Methixart, CholinFall, Tremonil, Trest), also known as methixene, is an anticholinergic used as an antiparkinsonian agent. It has also been reported to induce incomplete autophagy and cell death in metastatic cancer and brain metastases.
==See also== 3-Quinuclidinyl thiochromane-4-carboxylate Dothiepin
Excerpted from Wikipedia’s “methixene” article, available under the CC BY-SA 4.0 licence.