homatropine

Also known as 2-hydroxy-2-phenylacetic acid [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] ester, (1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 2-hydroxy-2-phenylacetate

Homatropine (Equipin, Isopto Homatropine) is an anticholinergic medication that is an antagonist at muscarinic acetylcholine receptors and thus the parasympathetic nervous system. It is used in eye drops as a cycloplegic (to temporarily paralyze accommodation), and as a mydriatic (to dilate the pupil).

Key facts

Drug.Verifiedfields: changed
Drug.Watchedfields: changed
Drug.verifiedrevid: 461770217
Drug.image: Homatropine.svg
Drug.image_class: skin-invert-image
Drug.MedlinePlus: a601006
Drug.legal_status: Rx only
Drug.CAS_number: 87-00-3
Drug.ATC_prefix: S01
Drug.ATC_suffix: FA05
Drug.PubChem: 6321423
Drug.DrugBank: DB00725
Drug.ChemSpiderID

Article

3 sections

Contents

Side effects
Contraindications
References

The related chemical compound homatropine methylbromide (methylhomatropine) is a different medication. Homatropine is less potent than atropine and has a shorter duration of action. It is available as the hydrobromide salt. Homatropine is also given as an atropine substitute, given to reverse the muscarinic and CNS effects associated with indirect cholinomimetic (anti-AChase) administration.