Structure via PubChem · Public domain (PubChem)
triprolidine
Sign in to saveAlso known as Actidil®, (E)-2-[3-(1-pyrrolidinyl)-1-p-toluenepropenyl]pyridine, trans-1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene, trans-1-(2-pyridyl)-3-pyrrolidino-1-p-tolylprop-1-ene, Triprolidin, Tripolidina, Triprolidinum
Triprolidine is an over-the-counter antihistamine with anticholinergic properties. It is used to combat the symptoms associated with allergies and is sometimes combined with other cold medications designed to provide general relief for flu-like symptoms. As with many antihistamines, the most common side effect is drowsiness.
Chemical data
- Formula
- C19H22N2
- Molecular weight
- 278.4 g/mol
- IUPAC name
- 2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine
- SMILES
- CC1=CC=C(C=C1)/C(=C\CN2CCCC2)/C3=CC=CC=N3
- InChIKey
- CBEQULMOCCWAQT-WOJGMQOQSA-N
- XLogP
- 3.9
- Polar surface area
- 16.1 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1982
- Admin. routes
- oral
- Indications
- allergic disease
via ChEMBL · EBI
Research
420 papers- Triprolidine.2006
- Triprolidine.2012
- Efficacy of Triprolidine in the Treatment of Temporary Sleep Disturbance.Journal of clinical pharmacology · 2021
- Bioavailability of Triprolidine as a Single Agent or in Combination With Pseudoephedrine: A Randomized, Open-Label Crossover Study in Healthy Volunteers.Clinical pharmacology in drug development · 2020
- Triprolidine: 104-week feeding study in rats.Fundamental and applied toxicology : official journal of the Society of Toxicology · 1995
via PubMed
Wikidata facts
- Mass
- 278.178299
- Has use
- medication
Show 7 more facts
- chemical formula
- C₁₉H₂₂N₂
- canonical SMILES
- CC1=CC=C(C=C1)C(=CCN2CCCC2)C3=CC=CC=N3
- isomeric SMILES
- CC1=CC=C(C=C1)/C(=C\CN2CCCC2)/C3=CC=CC=N3
- World Health Organisation international non-proprietary name
- triprolidine
- defined daily dose
- 7.5
- physically interacts with
- Histamine receptor H1
- Commons category
- Triprolidine
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Triprolidine is an over-the-counter antihistamine with anticholinergic properties. It is used to combat the symptoms associated with allergies and is sometimes combined with other cold medications designed to provide general relief for flu-like symptoms. As with many antihistamines, the most common side effect is drowsiness.
Triprolidine was patented in 1948 and came into medical use in 1953, and has mostly been replaced in popular medications by other antihistamines including diphenhydramine, promethazine, chlorpheniramine, as well as by second-generation antihistamines including loratadine and fexofenadine. Triprolidine remains an ingredient in the cold medicine Actifed in many territories.
Excerpted from Wikipedia’s “triprolidine” article, available under the CC BY-SA 4.0 licence.