thiethylperazine
Also known as TOR895, GS-95, Torecan®, Ethylthioperazine, 2-(ethylthio)-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine, 3-Ethylmercapto-10-(1'-methylpiperazinyl-4'-propyl)phenothiazine
Thiethylperazine (Torecan, Norzine) is an antiemetic of the phenothiazine class. It is an antagonist of dopamine receptors (DRD1, DRD2, DRD4) as well as of 5-HT2A, 5-HT2C receptors, mAChRs (1 through 5), α1 adrenergic receptor and H1 receptor.
Research
243 papers- Thiethylperazine.2006
- Thiethylperazine--Torecan.The Canadian journal of psychiatric nursing · 1967
- The influence of thiethylperazine on the absorption of effervescent aspirin in migraine.British journal of clinical pharmacology · 1976
- Thiethylperazine and tardive dyskinesia.Acta neurologica Scandinavica · 1984
- Case-control study of teratogenic potential of thiethylperazine, an anti-emetic drug.BJOG : an international journal of obstetrics and gynaecology · 2003
via PubMed
~2 min read
Article
8 sectionsContents
- Pharmacokinetics
- Distribution
- Metabolism
- Teratogenicity
- Antipsychotic activity
- Overdose
- Synthesis
- References
Thiethylperazine (Torecan, Norzine) is an antiemetic of the phenothiazine class. It is an antagonist of dopamine receptors (DRD1, DRD2, DRD4) as well as of 5-HT2A, 5-HT2C receptors, mAChRs (1 through 5), α1 adrenergic receptor and H1 receptor.
Thiethylperazine activates the transport protein ABCC1 that clears beta-amyloid from brains of mice.