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Nitroxazepine
Sign in to saveNitroxazepine (brand name Sintamil) is a tricyclic antidepressant (TCA) which was introduced by Ciba-Geigy (now Novartis) for the treatment of depression in India in 1982. It is also indicated for the treatment of nocturnal enuresis. Nitroxazepine acts as a serotonin-norepinephrine reuptake inhibitor and has similar effects to imipramine, but with certain advantages, such as lower anticholinergic side effects.
Chemical data
- Formula
- C18H19N3O4
- Molecular weight
- 341.4 g/mol
- IUPAC name
- 5-[3-(dimethylamino)propyl]-8-nitrobenzo[b][1,4]benzoxazepin-6-one
- SMILES
- CN(C)CCCN1C2=CC=CC=C2OC3=C(C1=O)C=C(C=C3)[N+](=O)[O-]
- InChIKey
- CGYWLLGTCBIGSR-UHFFFAOYSA-N
- XLogP
- 2.8
- Polar surface area
- 78.6 Ų
- H-bond donors
- 0
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 341.138
Show 3 more facts
- chemical formula
- C₁₈H₁₉N₃O₄
- canonical SMILES
- CN(C)CCCN1C2=CC=CC=C2OC3=C(C1=O)C=C(C=C3)[N+](=O)[O-]
- Commons category
- Nitroxazepine
via Wikidata · CC0
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Encyclopedic overview
1 sectionsContents
- References
Nitroxazepine (brand name Sintamil) is a tricyclic antidepressant (TCA) which was introduced by Ciba-Geigy (now Novartis) for the treatment of depression in India in 1982. It is also indicated for the treatment of nocturnal enuresis. Nitroxazepine acts as a serotonin-norepinephrine reuptake inhibitor and has similar effects to imipramine, but with certain advantages, such as lower anticholinergic side effects.
==References==
Excerpted from Wikipedia’s “Nitroxazepine” article, available under the CC BY-SA 4.0 licence.