Structure via PubChem · Public domain (PubChem)
deptropine
Sign in to saveAlso known as dibenzheptropine, endo-3-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)oxy]-1alphaH,5alphaH-tropane, endo-3-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)oxy]-8-methyl-8-azabicyclo[3.2.1]octane
Deptropine (Brontina) also known as dibenzheptropine, is an antihistamine with anticholinergic properties acting at the H1 receptor. It is usually marketed as the citrate salt.
Chemical data
- Formula
- C23H27NO
- Molecular weight
- 333.5 g/mol
- IUPAC name
- 8-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenyloxy)-8-azabicyclo[3.2.1]octane
- SMILES
- CN1C2CCC1CC(C2)OC3C4=CC=CC=C4CCC5=CC=CC=C35
- InChIKey
- ZWPODSUQWXAZNC-UHFFFAOYSA-N
- XLogP
- 4.8
- Polar surface area
- 12.5 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- allergic disease
via ChEMBL · EBI
Research
56 papers- The Antihistamine Deptropine Induces Hepatoma Cell Death through Blocking Autophagosome-Lysosome Fusion.Cancers · 2020
- FDA-drug screening identifies deptropine inhibiting hepatitis E virus involving the NF-κB-RIPK1-caspase axis.Antiviral research · 2019
- [Glycopyrrolate, an alternative to deptropine citratie when treating sialorrhea].Journal de pharmacie de Belgique · 2010
- [Deptropine still prescribed for 0-4 year olds].Nederlands tijdschrift voor geneeskunde · 2000
- Systems Biology-Driven Discovery of Host-Targeted Therapeutics for Oropouche Virus: Integrating Network Pharmacology, Molecular Docking, and Drug Repurposing.Pharmaceuticals (Basel, Switzerland) · 2025
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 333.2093
Show 6 more facts
- chemical formula
- C₂₃H₂₇NO
- World Health Organisation international non-proprietary name
- deptropine
- isomeric SMILES
- CN1[C@@H]2CC[C@H]1C[C@H](C2)OC3C4=CC=CC=C4CCC5=C3C=CC=C5
- canonical SMILES
- CN1C2CCC1CC(C2)OC3C4=CC=CC=C4CCC5=C3C=CC=C5
- subject has role
- H1 antagonist
- defined daily dose
- 2
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
1 sectionsContents
- References
Deptropine (Brontina) also known as dibenzheptropine, is an antihistamine with anticholinergic properties acting at the H1 receptor. It is usually marketed as the citrate salt.
== References ==
Excerpted from Wikipedia’s “deptropine” article, available under the CC BY-SA 4.0 licence.
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via Wikidata sitelinks · CC0